Promoting validation and cross-phylogenetic integration in model organism research

Author:

Cheng Keith C.12ORCID,Burdine Rebecca D.3ORCID,Dickinson Mary E.45,Ekker Stephen C.6,Lin Alex Y.1,Lloyd K. C. Kent78,Lutz Cathleen M.9,MacRae Calum A.10,Morrison John H.1112,O'Connor David H.13,Postlethwait John H.14,Rogers Crystal D.15,Sanchez Susan16,Simpson Julie H.17,Talbot William S.18,Wallace Douglas C.19,Weimer Jill M.20,Bellen Hugo J.21ORCID

Affiliation:

1. Penn State College of Medicine 1 Department of Pathology , , Hershey, PA 17033 , USA

2. Pennsylvania State University 2 Institute for Computational and Data Sciences , , Park, PA 16802 , USA

3. Princeton University 3 Department of Molecular Biology , , Princeton, NJ 08540 , USA

4. Baylor College of Medicine 4 Department of Molecular Physiology and Biophysics , , Houston, TX 77007 , USA

5. Baylor College of Medicine 5 Department of Molecular and Human Genetics , , Houston, TX 77007 , USA

6. Department of Biochemistry and Molecular Biology 6 , Mayo Clinic, Rochester, MN 55906 , USA

7. Mouse Biology Program, School of Medicinel 7 , University of California Davis, Davis, CA 95618 , USA

8. University of California Davis 8 Department of Surgery, School of Medicine , , Davis, CA 95618 , USA

9. Genetic Resource Science 9 The Jackson Laboratory , , Bar Harbor, ME 04609 , USA

10. Department of Medicine 10 , Brigham and Women's Hospital and Harvard Medical School, 360 Longwood Avenue, Boston, MA 02215 , USA

11. University of California Davis 11 California National Primate Research Center , , Davis, CA 95616 , USA

12. University of California Davis 12 Department of Neurology , , Davis, CA 95616 , USA

13. University ofWisconsin-Madison 13 Department of Pathology and Laboratory Medicine , , Madison, WI 53711 , USA

14. University of Oregon 14 Institute of Neuroscience , , Eugene, OR 97403 , USA

15. School of Veterinary Medicine 15 , University of California Davis, Davis, CA 95616 , USA

16. College of Veterinary Medicine 16 Department of Infectious Diseases , , The University of Georgia, Athens, GA 30602 , USA

17. University of California 17 Department of Molecular, Cell and Developmental Biology , , Santa Barbara, CA 93117 , USA

18. Stanford University 18 Department of Developmental Biology , , Stanford, CA 94305 , USA

19. Children's Hospital of Philadelphia 19 Department of Pediatrics , , Philadelphia, PA 19104 , USA

20. Sanford Research 20 Pediatrics and Rare Diseases Group , , Sioux Falls, SD 57104 , USA

21. Baylor College of Medicine 21 Department of Molecular and Human Genetics, Neurological Research Institute (TCH) , , Houston, TX 77007 , USA

Abstract

ABSTRACT Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organism-based chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National Institutes of Health across more than 10 weeks yielded important suggestions for improving the rigor, validation, reproducibility and translatability of MO research. The effort clarified challenges and opportunities for developing and integrating tools and resources. Maintenance of critical existing infrastructure and the implementation of suggested improvements will play important roles in maintaining productivity and facilitating the validation of animal models of human biology and disease.

Funder

Office of Extramural Research, National Institutes of Health

National Institutes of Health

Howard Hughes Medical Institute

Publisher

The Company of Biologists

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology (miscellaneous),Medicine (miscellaneous),Neuroscience (miscellaneous)

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