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Elastic fibres

Published:2002-07-15 Issue:14 Volume:115 Page:2817-2828
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Kielty Cay M.¹,Sherratt Michael J.²,Shuttleworth C. Adrian²

Affiliation:

1. School of Medicine, University of Manchester, Manchester M13 9PT, UK

2. School of Biological Sciences, University of Manchester, Manchester M13 9PT,UK

Abstract

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as blood vessels, lungs and skin with the critical properties of elasticity and resilience. The biology of elastic fibres is complex because they have multiple components, a tightly regulated developmental deposition, a multi-step hierarchical assembly and unique biomechanical functions. However, their molecular complexity is at last being unravelled by progress in identifying interactions between component molecules, ultrastructural analyses and studies of informative mouse models.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/115/14/2817/1473597/2817.pdf

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