Affiliation:
1. Department of Medical BioSciences Research Institute for Medical Innovation Radboud university medical center PO Box 9101 Nijmegen 6500 HB The Netherlands
2. MedSkin Solutions Dr. Suwelack AG 48727 Billerbeck Germany
3. Department of Dermatology Radboud university medical center Nijmegen 6525 GA The Netherlands
Abstract
AbstractElastin, a fibrous extracellular matrix (ECM) protein, is the main component of elastic fibers that are involved in tissues’ elasticity and resilience, enabling them to undergo reversible extensibility and to endure repetitive mechanical stress. After wounding, it is challenging to regenerate elastic fibers and biomaterials developed thus far have struggled to induce its biosynthesis. This review provides a comprehensive summary of elastic fibers synthesis at the cellular level and its implications for biomaterial formulation, with a particular focus on dermal substitutes. The review delves into the intricate process of elastogenesis by cells and investigates potential triggers for elastogenesis encompassing elastin‐related compounds, ECM components, and other molecules for their potential role in inducing elastin formation. Understanding of the elastogenic processes is essential for developing biomaterials that trigger not only the synthesis of the elastin protein, but also the formation of a functional and branched elastic fiber network.
Funder
H2020 Marie Skłodowska-Curie Actions