The intrusion detection system (IDS) has lower speed, less adaptability and lower detection accuracy especially for small samples sets. This paper presents a detection model based on normalized mutual antibodies information feature selection and adaptive quantum artificial immune with cooperative evolution of multiple operators (NMAIFS MOP-AQAI). First, for a high intrusion speed, the NMAIFS is used to achieve an effective reduction for high-dimensional features. Then, the best feature vectors are sent to the MOP-AQAI classifier, in which, vaccination strategy, the quantum computing, and cooperative evolution of multiple operators are adopted to generate excellent detectors. Lastly, the data is fed into NMAIFS MOP-AQAI and ultimately generates accurate detection results. The experimental results on real abnormal data demonstrate that the NMAIFS MOP-AQAI has higher detection accuracy, lower false negative rate and a higher adaptive performance than the existing anomaly detection methods, especially for small samples sets.