Bioanalytical Approaches to Quantify “Total” and “Free” Therapeutic Antibodies and Their Targets: Technical Challenges and PK/PD Applications Over the Course of Drug Development-Reference-Cited by-同舟云学术

Bioanalytical Approaches to Quantify “Total” and “Free” Therapeutic Antibodies and Their Targets: Technical Challenges and PK/PD Applications Over the Course of Drug Development

Published:2011-01-15 Issue:1 Volume:13 Page:99-110
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Lee Jean W.,Kelley Marian,King Lindsay E.,Yang Jihong,Salimi-Moosavi Hossein,Tang Meina T.,Lu Jian-Feng,Kamerud John,Ahene Ago,Myler Heather,Rogers Cindy

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-011-9251-3.pdf

Reference25 articles.

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3. Lee JW, Devanarayan V, Barrett YC, Weiner R, Allinson J, Fountain S, et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharm Res. 2006;23(2):312–28.

4. Betts AM, Clark TH, Yang J, Treadway JL, Li M, Giovanelli MA, et al. The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010;333(1):2–13.

5. Kuang B, King L, Wang H. Therapeutic monoclonal antibody concentration monitoring: free or total? Bioanalysis. 2010;2(6):1125–40.

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