Solving selectivity issues in LBAs: case study using Gyrolab to quantify CB307, a bispecific Humabody in human serum-Reference-Cited by-同舟云学术

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Solving selectivity issues in LBAs: case study using Gyrolab to quantify CB307, a bispecific Humabody in human serum

Published:2024-07-03 Issue:14 Volume:16 Page:757-769
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Wilford Thomas¹,Bartlett Phillip D²,Schlag Anna²,Jasaitis Lukas²,Pandha Hardev³,Pierce Andrew J²,Hughes Richard¹

Affiliation:

1. Resolian, Fordham, Cambridgeshire CB7 5WW, United Kingdom of Great Britain & Northern Ireland

2. Crescendo Biologics Limited, Cambridge CB22 3AT, United Kingdom of Great Britain & Northern Ireland

3. University of Surrey, School of Biosciences, Guildford GU2 7XH, Surrey, United Kingdom of Great Britain & Northern Ireland

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/17576180.2024.2365545

Reference28 articles.

1. Meeting the demands of regulatory requirements: the significance of ADME

2. Bioanalytical Approaches to Quantify “Total” and “Free” Therapeutic Antibodies and Their Targets: Technical Challenges and PK/PD Applications Over the Course of Drug Development

3. Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)

4. Parallelism experiments to evaluate matrix effects, selectivity and sensitivity in ligand-binding assay method development: pros and cons

5. Are matrix effects the Achilles heel in the bioanalysis of biotherapeutics by ligand-binding assays?

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