The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis-Reference-Cited by-同舟云学术

The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis

Published:2010-01-20 Issue:1 Volume:333 Page:2-13
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Betts Alison M.,Clark Tracey H.,Yang Jianxin,Treadway Judith L.,Li Mei,Giovanelli Michael A.,Abdiche Yasmina,Stone Donna M.,Paralkar Vishwas M.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference28 articles.

1. Use of pharmacokinetic/ pharmacodynamic modelling for starting dose selection in first-in-human trials of high-risk biologics

2. The role of mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modelling in translational research of biologics

3. High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

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