Physiologically based pharmacokinetic (PBPK) model that describes enhanced FcRn-dependent distribution of monoclonal antibodies (mAbs) by pI-engineering in mice-Reference-Cited by-同舟云学术

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Physiologically based pharmacokinetic (PBPK) model that describes enhanced FcRn-dependent distribution of monoclonal antibodies (mAbs) by pI-engineering in mice

Published:2023-12 Issue: Volume:53 Page:100506
ISSN:1347-4367
Container-title:Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Naoi Sotaro^ORCID,Yamane Mizuki,Nemoto Takayuki,Kato Motohiro,Saito Ryoichi,Tachibana Tatsuhiko

Funder

Chugai Pharmaceutical

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference27 articles.

1. The state-of-play and future of antibody therapeutics;Elgundi;Adv Drug Deliv Rev,2016

2. Antibodies to watch in 2016;Reichert;mAbs,2016

3. Monoclonal antibodies in human cancer;Mellstedt;Drugs Today,2003

4. Engineering antibodies for therapy;Presta;Curr Pharmaceut Biotechnol,2002

5. FcRn: the neonatal Fc receptor comes of age;Roopenian;Nat Rev Immunol,2007

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