Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis-Reference-Cited by-同舟云学术

Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis

Published:2019-12-01 Issue:11 Volume:200 Page:1381-1391
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

McElvaney Oliver J.¹²^ORCID,Zaslona Zbigniew³,Becker-Flegler Katrin⁴,Palsson-McDermott Eva M.³,Boland Fiona⁵,Gunaratnam Cedric²,Gulbins Erich⁴,O’Neill Luke A.³,Reeves Emer P.¹,McElvaney Noel G.¹²

Affiliation:

1. Irish Centre for Genetic Lung Disease, Department of Medicine, and

2. Cystic Fibrosis Unit, Beaumont Hospital, Dublin, Ireland

3. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; and

4. Department of Molecular Biology, University Duisburg-Essen, Essen, Germany

5. Division of Biostatistics and Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

https://www.atsjournals.org/doi/pdf/10.1164/rccm.201905-1013OC

Reference62 articles.

1. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

2. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

3. Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

4. Gout-associated uric acid crystals activate the NALP3 inflammasome

5. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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