Signatures of glial activity can be detected in the CSF proteome-Reference-Cited by-同舟云学术

Signatures of glial activity can be detected in the CSF proteome

Published:2022-06-06 Issue:24 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Eninger Timo¹²,Müller Stephan A.³⁴,Bacioglu Mehtap¹²⁵^ORCID,Schweighauser Manuel¹²^ORCID,Lambert Marius¹²,Maia Luis F.¹⁶⁷^ORCID,Neher Jonas J.¹²^ORCID,Hornfeck Sarah M.¹²⁵^ORCID,Obermüller Ulrike¹²^ORCID,Kleinberger Gernot⁸⁹,Haass Christian³⁸⁹,Kahle Philipp J.²¹⁰^ORCID,Staufenbiel Matthias¹²,Ping Lingyan¹¹,Duong Duc M.¹¹,Levey Allan I.¹¹^ORCID,Seyfried Nicholas T.¹¹,Lichtenthaler Stefan F.³⁴⁹^ORCID,Jucker Mathias¹²^ORCID,Kaeser Stephan A.¹²

Affiliation:

1. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany

2. German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany

3. German Center for Neurodegenerative Diseases, 81377 Munich, Germany

4. Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, 80333 Munich, Germany

5. Graduate Training Centre of Neuroscience, University of Tübingen, 72076 Tübingen, Germany

6. Neurology Department, Centro Hospitalar Universitário do Porto, 4099-001 Porto, Portugal

7. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-393 Portugal

8. Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, 80539 Munich, Germany

9. Munich Cluster for Systems Neurology, 81377 Munich, Germany

10. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany

11. Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322

Abstract

Significance Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease (AD and PD). What is still needed are clinically relevant biomarkers for deciphering such glial states in AD and PD patients. To this end, we applied proteome analysis in cerebrospinal fluid (CSF) of mouse models of AD and PD pathology. This allowed us to identify a panel of glial CSF proteins that largely match the transcriptomic changes. The identified proteins can also be quantified in human CSF and show changes in AD patients, supporting their relevance as biomarker candidates to stage glial activation in patients with neurodegenerative diseases.

Funder

Cure Alzheimer''''s Fund

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Deutsche Forschungsgemeinschaft

EU Joint Programme (JPND) PMG-AD

Bundesministerium für Bildung und Forschung

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2119804119