A mitochondrial ADXR–ADX–P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in <i>Arabidopsis</i>-Reference-Cited by-同舟云学术

A mitochondrial ADXR–ADX–P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in Arabidopsis

Published:2022-01-19 Issue:4 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Bellido Andrés Martin¹,Distéfano Ayelén Mariana¹^ORCID,Setzes Nicolás¹,Cascallares María Milagros¹^ORCID,Oklestkova Jana²^ORCID,Novak Ondrej²^ORCID,Ramirez Javier Alberto³⁴^ORCID,Zabaleta Eduardo J.¹^ORCID,Fiol Diego F.¹^ORCID,Pagnussat Gabriela C.¹^ORCID

Affiliation:

1. Instituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina

2. Laboratory of Growth Regulators, Faculty of Science, Institute of Experimental Botany and Palacký University, The Czech Academy of Sciences, 78371 Olomouc, Czech Republic

3. Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina

4. Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR), Universidad de Buenos Aires, CONICET, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina

Abstract

Significance Mitochondrial adrenodoxins (ADXs) are small iron–sulfur proteins that function as mobile shuttles transferring electrons. Their function has been largely known in animals, as they transfer electrons between an adrenodoxin reductase (ADXR) and mitochondrial P450s, which is a crucial step that leads to steroidogenesis. Here we show that a functional mitochondrial ADX–ADXR–P450 pathway is essential for steroid biosynthesis and that its function is required for plant sexual reproduction.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2000482119

Reference40 articles.

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