Slow expanders invade by forming dented fronts in microbial colonies

Author:

Lee Hyunseok1ORCID,Gore Jeff1,Korolev Kirill S.2ORCID

Affiliation:

1. Physics of Living Systems Group, Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139;

2. Department of Physics, Graduate Program in Bioinformatics, Biological Design Center, Boston University, Boston, MA 02215

Abstract

Significance Living organisms never cease to evolve, so there is a significant interest in predicting and controlling evolution in all branches of life sciences. The most basic question is whether a trait should increase or decrease in a given environment. The answer seems to be trivial for traits such as the growth rate in a bioreactor or the expansion rate of a tumor. Yet, it has been suggested that such traits can decrease, rather than increase, during evolution. Here, we report a mutant that outcompeted the ancestor despite having a slower expansion velocity when in isolation. To explain this observation, we developed and validated a theory that describes spatial competition between organisms with different expansion rates and arbitrary competitive interactions.

Funder

Foundation for the National Institutes of Health

Alfred P. Sloan Foundation

Simons Foundation

HHS | NIH | National Institute of General Medical Sciences

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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