Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain-Reference-Cited by-同舟云学术

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Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Published:2018 Issue: Volume:51 Page:
ISSN:0033-5835
Container-title:Quarterly Reviews of Biophysics
language:en
Short-container-title:Quart. Rev. Biophys.

Author:

Palermo Giulia,Chen Janice S.,Ricci Clarisse G.,Rivalta Ivan,Jinek Martin,Batista Victor S.,Doudna Jennifer A.,McCammon J. Andrew

Abstract

Abstract

Publisher

Cambridge University Press (CUP)

Subject

Biophysics

Reference61 articles.

1. The development of cryo-EM into a mainstream structural biology technique

2. Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

3. Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

4. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

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