A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9-Reference-Cited by-同舟云学术

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Author:

Dagdas Yavuz S.¹^ORCID,Chen Janice S.²^ORCID,Sternberg Samuel H.³^ORCID,Doudna Jennifer A.²³⁴⁵^ORCID,Yildiz Ahmet²⁶^ORCID

Affiliation:

1. Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.

2. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

3. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

4. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

5. Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

6. Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

A conformational checkpoint of Cas9 enables on-target cleavage while blocking access to the active state at off-target sites.

Funder

National Science Foundation

National Institutes of Health

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

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