Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

Author:

Maas Brian M.,Francis Owen,Mollan Katie R.,Lee Cynthia,Cottrell Mackenzie L.,Prince Heather M. A.,Sykes Craig,Trezza Christine,Torrice Chad,White Nicole,Malone Stephanie,Hudgens Michael G.,Sharpless Norman E.,Dumond Julie B.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

National Institute on Aging

National Center for Research Resources

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference33 articles.

1. Management of human immunodeficiency virus infection in advanced age;M Greene;JAMA,2013

2. HIV infection, inflammation, immunosenescence, and aging;SG Deeks;Annu Rev Med,2011

3. Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy;JAE Nelson;Aging cell,2012

4. HIV-1 transgenic rats display alterations in immunophenotype and cellular responses associated with aging;SJ Abbondanzo;PLoS One,2014

5. Seifert SM, Castillo-Mancilla JR, Erlandson KM, Clayton C, Zheng JH, Bushman LR, et al. Cumulative tenofovir exposure is associated with decreased BMD in young and old HIV-infected adults on tenofovir based regimens 17th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy; Washington, D.C.2016.

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