Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine

Author:

Dumond Julie B.1ORCID,Bay Camden P.2,Nelson Julie A. E.3,Davalos Angel2,Edmonds Andrew4,De Paris Kristina3,Sykes Craig1,Anastos Kathryn5,Sharma Roopali6,Kassaye Seble7,Tamraz Bani8,French Audrey L.9,Gange Stephen10,Ofotokun Ighovwerha11,Fischl Margaret A.12,Vance David E.13,Adimora Adaora A.14

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA

2. Department of Biostatistics, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina, USA

3. Department of Microbiology and Immunology, UNC School of Medicine, Chapel Hill, North Carolina, USA

4. Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina, USA

5. Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA

6. Touro College of Pharmacy, New York, New York, USA

7. Georgetown University, Washington, DC, USA

8. University of California San Francisco, San Francisco, California, USA

9. CORE Center, Stroger Hospital of Cook County, Chicago, Illinois, USA

10. Johns Hopkins University, Baltimore, Maryland, USA

11. Emory University School of Medicine, Department of Medicine, Division of Infectious Disease and Grady Healthcare System, Atlanta, Georgia, USA

12. University of Miami Miller School of Medicine, Miami, Florida, USA

13. School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA

14. UNC School of Medicine, Chapel Hill, North Carolina, USA

Abstract

The altered immune states of aging and HIV infection may affect intracellular metabolism of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC); increased cellular senescence decreases FTC-triphosphate (FTCtp) concentrations. The effects of age and inflammation on the ratio of intracellular metabolites (IMs; tenofovir diphosphate [TFVdp] and FTCtp) to their endogenous nucleotides (ENs; dATP and dCTP), a potential treatment efficacy marker, were assessed among participants of the Women’s Interagency HIV Study (WIHS), who ranged from 25 to 75 years.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Research Resources

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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