Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum

Author:

van der Veldt SuzanneORCID,Etter Guillaume,Mosser Coralie-AnneORCID,Manseau FrédéricORCID,Williams SylvainORCID

Abstract

The hippocampal spatial code’s relevance for downstream neuronal populations—particularly its major subcortical output the lateral septum (LS)—is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatial tuning of LS GABAergic cells to those of dorsal CA3 and CA1 cells. We identified a significant number of LS cells that are modulated by place, speed, acceleration, and direction, as well as conjunctions of these properties, directly comparable to hippocampal CA1 and CA3 spatially modulated cells. Interestingly, Bayesian decoding of position based on LS spatial cells reflected the animal’s location as accurately as decoding using the activity of hippocampal pyramidal cells. A portion of LS cells showed stable spatial codes over the course of multiple days, potentially reflecting long-term episodic memory. The distributions of cells exhibiting these properties formed gradients along the anterior–posterior and dorsal–ventral axes of the LS, directly reflecting the topographical organization of hippocampal inputs to the LS. Finally, we show using transsynaptic tracing that LS neurons receiving CA3 and CA1 excitatory input send projections to the hypothalamus and medial septum, regions that are not targeted directly by principal cells of the dorsal hippocampus. Together, our findings demonstrate that the LS accurately and robustly represents spatial, directional as well as self-motion information and is uniquely positioned to relay this information from the hippocampus to its downstream regions, thus occupying a key position within a distributed spatial memory network.

Funder

canadian institutes of health research

nserc

Tier 1 Canada Research Chair

CIHR Vanier

McGill University

Fonds de Recherche du Québec - Santé

Publisher

Public Library of Science (PLoS)

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference124 articles.

1. Characterization of GABAergic neurons in the mouse lateral septum: a double fluorescence in situ hybridization and immunohistochemical study using tyramide signal amplification;C Zhao;PLoS ONE,2013

2. Distribution of vesicular glutamate transporter-2 messenger ribonucleic acid and protein in the septum-hypothalamus of the rat;W Lin;Endocrinology,2003

3. Structural evidence for functional domains in the rat hippocampus;PY Risold;Science,1996

4. Transformation of a spatial map across the hippocampal-lateral septal circuit;D Tingley;Neuron,2018

5. The connections of the septal region in the rat;LW Swanson;J Comp Neurol,1979

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