Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

Author:

Puthenveetil SujietORCID,He Haiyin,Loganzo Frank,Musto Sylvia,Teske Jesse,Green Michael,Tan Xingzhi,Hosselet Christine,Lucas Judy,Tumey L. Nathan,Sapra Puja,Subramanyam Chakrapani,O’Donnell Christopher J.,Graziani Edmund I.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference36 articles.

1. Expanding the Reach of Antibody–Drug Conjugates;RVJ Chari;ACS Med Chem Lett,2016

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3. Antibody-targeted drugs for the therapy of cancer;GA Pietersz;J Drug Target,1994

4. Current methods for the synthesis of homogeneous antibody-drug conjugates;AM Sochaj;Biotechnol Adv,2015

5. Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models;F Lhospice;Mol Pharm,2015

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