Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models-Reference-Cited by-同舟云学术

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models

Published:2015-02-09 Issue:6 Volume:12 Page:1863-1871
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Lhospice F.¹,Brégeon D.¹,Belmant C.¹,Dennler P.²,Chiotellis A.³,Fischer E.²,Gauthier L.¹,Boëdec A.¹,Rispaud H.¹,Savard-Chambard S.¹,Represa A.¹,Schneider N.¹,Paturel C.¹,Sapet M.¹,Delcambre C.¹,Ingoure S.¹,Viaud N.¹,Bonnafous C.¹,Schibli R.²³,Romagné F.⁴

Affiliation:

1. Innate Pharma SA, F13276 Marseille, France

2. Center for Radiopharmaceutical Sciences, ETH-PSI-USZ, Paul Scherrer Institute, 5232 Villigen, Switzerland

3. Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland

4. MI-mAbs (C/0 CIML), Parc Scientifique et Technologique de Luminy, Avenue de Luminy case 906, F13288 Marseille Cedex 9, France

Funder

Swiss National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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