Complete Genome Sequence of Soil Bacterium <i>Burkholderia</i> sp. Strain FERM BP-3421, a Producer of Spliceostatins-Reference-Cited by-同舟云学术

Complete Genome Sequence of Soil Bacterium Burkholderia sp. Strain FERM BP-3421, a Producer of Spliceostatins

Published:2023-05-17 Issue:5 Volume:12 Page:
ISSN:2576-098X
Container-title:Microbiology Resource Announcements
language:en
Short-container-title:Microbiol Resour Announc

Author:

Kunakom Sylvia¹²,Adaikpoh Barbara I.¹²^ORCID,Tran Tuan Anh¹²,Eustáquio Alessandra S.¹²^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

2. Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

Here, we report the complete genome sequence of Burkholderia sp. strain FERM BP-3421, a bacterium isolated previously from a soil sample in Japan. Strain FERM BP-3421 produces spliceostatins, which are splicing modulatory antitumor agents that advanced to preclinical development. The genome is composed of four circular replicons of 3.90, 3.0, 0.59, and 0.24 Mbp.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/mra.00111-23

Reference13 articles.

1. New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

2. Cytotoxic Spliceostatins fromBurkholderiasp. and Their Semisynthetic Analogues

3. New Antitumor Substances, FR901463, FR901464 and FR901465. II. Activities against Experimental Tumors in Mice and Mechanism of Action.

4. Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads

5. Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

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