Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

Author:

Benavides-Serrato Angelica,Lee Jihye,Holmes Brent,Landon Kenna A.,Bashir Tariq,Jung Michael E.,Lichtenstein Alan,Gera JosephORCID

Funder

NCI

US Department of Veterans Affairs

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference44 articles.

1. Emerging insights into the molecular and cellular basis of glioblastoma;GP Dunn;Genes Dev,2012

2. Glioblastoma: from molecular pathology to targeted treatment;TF Cloughesy;Annual review of pathology,2014

3. Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance;QW Fan;Curr Top Microbiol Immunol,2010

4. The neurobiology of gliomas: from cell biology to the development of therapeutic approaches;M Westphal;Nat Rev Neurosci,2011

5. New strategies in the molecular targeting of glioblastoma: how do you hit a moving target?;TF Cloughesy;Clinical cancer research: an official journal of the American Association for Cancer Research,2011

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