High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design

Author:

Paladino Antonella,Civera Monica,Belvisi Laura,Colombo GiorgioORCID

Funder

Associazione Italiana per la Ricerca sul Cancro

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference58 articles.

1. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand;J-P. Xiong,2002

2. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics;T. Xiao,2004

3. Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin;J. F. Van Agthoven,2014

4. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression;J. S. Desgrosellier,2009

5. Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis;J. D. Hood,2003

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