Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism-Reference-Cited by-同舟云学术

Design and Pharmacological Characterization of α₄β₁ Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism

Published:2023-03-28 Issue:7 Volume:66 Page:5021-5040
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Anselmi Michele¹^ORCID,Baiula Monica²^ORCID,Spampinato Santi²,Artali Roberto³^ORCID,He Tingting¹,Gentilucci Luca¹⁴^ORCID

Affiliation:

1. Department of Chemistry “G. Ciamician”, University of Bologna, Via Selmi 2, 40126 Bologna, Italy

2. Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy

3. Scientia Advice, 20832 Desio, Italy

4. Health Sciences & Technologies (HST) CIRI, University of Bologna, Via Tolara di Sopra 41/E, 40064 Ozzano Emilia, Italy

Funder

China Scholarship Council

Fondazione CarisBo

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c02098

Reference87 articles.

1. Alpha 4 Integrin Antagonists

2. VLA-4 antagonists: Potent inhibitors of lymphocyte migration

3. α4 Integrin Binding Interfaces on VCAM-1 and MAdCAM-1

4. The pathophysiologic role of alpha 4 integrins in vivo.

5. Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives

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