Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach-Reference-Cited by-同舟云学术

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Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach

Published:2021-04-01 Issue:4 Volume:61 Page:1875-1888
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Paladino Antonella¹^ORCID,D’Angelo Fulvio¹²^ORCID,Noviello Teresa Maria Rosaria¹³,Iavarone Antonio²⁴⁵,Ceccarelli Michele¹³^ORCID

Affiliation:

1. BIOGEM Istituto di Ricerche Genetiche “G. Salvatore”, via Camporeale, Ariano Irpino 83031, Italy

2. Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, New York, New York 10032, United States

3. Department of Electrical Engineering and Information Technology (DIETI), University of Naples “Federico II”, Via Claudio 21, Naples 80128, Italy

4. Department of Pathology and Cell Biology, Columbia University Medical Center, 1130 St Nicholas Ave, New York , New York 10032 United States

5. Department of Neurology, Columbia University Medical Center, 1130 St Nicholas Ave, New York, New York 10032, United States

Funder

Associazione Italiana per la Ricerca sul Cancro

CINECA Supercomputing

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c00296

Reference67 articles.

1. The integrated landscape of driver genomic alterations in glioblastoma

2. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

3. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas

4. Rare variants inSOS2andLZTR1are associated with Noonan syndrome

5. Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

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