Specific serum biomarkers inflammation in sarcoidosis and tuberculosis

Abstract

In order to study the diagnostic and prognosis role of a complex of serum biomarkers of inflammation in active sarcoidosis and tuberculosis (angiotensin-converting enzyme (ACE), adenosine deaminase (ADA), C-reactive protein (CRP), free radicals (FvR), resistance to oxidative stress (OSR), lipid profile, indicator of lipoidosis activity (PAL) according to the developed patented formula: PAL = TC/LDLxc+TGL, correlation coefficient (СС) according to the developed patented formula: CC  = FCT/ADA), a series of single-center prospective dynamic studies were conducted: 303 patients with respiratory sarcoidosis before treatment and every 2-6 months of treatment for 3 years (patients with severe diseases of the  cardiovascular system and taking angiotensin-converting enzyme inhibitor were excluded): group 1-193 patients without exacerbation of sarcoidosis (men/women 124 (65%)/69 (35%), median age 47.3, index body weight 24.9, group 2 – 51 patients with exacerbation not treated with corticosteroids (men/women 34 (66.7%)/17 (33.3%), median age 39.5, index body weight 29.2, group 3-59 patients with exacerbation treated with corticosteroids (men/women 31 (52.5%)/28 (47.4%), median age 34.7, index body weight 29.1; 273 patients before and after 2-6 months of treatment: 151 patients with sarcoidosis and 122 patients with tuberculosis. In sarcoidosis, inflammation was characterized by increased ACE, ADA, normal CRP, dyslipidemia with decreased PAL.In tuberculosis- increased ADA, CRP, normal ACE, dyslipidemia and lowel PAL than in sarcoidosis. In sarcoidosis, CC (ACE / ADA ratio) reflects inflammatory activity with a sensitivity of 85%, specificity of 78.8%, efficiency of 80%. The complex of ACE, ADA, CC, CRP, PAL, FvR, OSR is an effective tool for monitoring granulomatous and endogenous systemic inflammation in sarcoidosis and tuberculosis.