West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018

Author:

Sinigaglia Alessandro1,Pacenti Monia2,Martello Thomas1,Pagni Silvana21,Franchin Elisa21,Barzon Luisa21ORCID

Affiliation:

1. Department of Molecular Medicine, University of Padova, Padova, Italy

2. Microbiology and Virology Unit, Padova University Hospital, Padova, Italy

Abstract

In 2018, there was a large West Nile virus (WNV) outbreak in northern Italy. We observed five atypical cases of WNV infection that were characterised by the presence of WNV RNA and WNV IgG at the time of diagnosis, but no IgM response during follow-up. Neutralisation assays demonstrated pre-existing Usutu virus immunity in all patients. Besides challenging diagnosis, the immunological crosstalk between the two viruses warrants further investigation on possible cross-protection or infection enhancement effects.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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