Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018-Reference-Cited by-同舟云学术

Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018

Published:2018-11-22 Issue:47 Volume:23 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Golparian Daniel¹,Rose Lisa²,Lynam Almida³,Mohamed Aia²,Bercot Beatrice⁴,Ohnishi Makoto⁵,Crowley Brendan⁶⁷²,Unemo Magnus⁶¹

Affiliation:

1. WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Swedish Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

2. Department of Clinical Microbiology, University of Dublin, Trinity College, St. James’s Hospital, Dublin, Ireland

3. Guide Clinic, St. James’s Hospital, Dublin, Ireland

4. APHP, St Louis Hospital, Laboratory of Microbiology; French National Reference Center for Bacterial STI, Associated laboratory for gonococci; Paris Diderot University, IAME, Sorbonne Paris Cité, Paris, France

5. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

6. Authors contributed equally to the work and share joint authorship

7. National Gonococcal Reference Laboratory, St. James’s Hospital, Dublin, Ireland

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating penA-60.001. Global awareness of spreading ceftriaxone-resistant gonococcal strains that threaten recommended dual therapies is essential.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference18 articles.

1. New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan.;Nakayama;Antimicrob Agents Chemother,2016

2. Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain.;Lahra;Emerg Infect Dis,2018

3. Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017.;Lefebvre;Emerg Infect Dis,2018

4. Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017.;Terkelsen;Euro Surveill,2017

5. Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.;Poncin;Euro Surveill,2018

Cited by 84 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In silico gepotidacin target mining among 33 213 global Neisseria gonorrhoeae genomes from 1928 to 2023 combined with gepotidacin MIC testing of 22 gonococcal isolates with different GyrA and ParC substitutions;Journal of Antimicrobial Chemotherapy;2024-07-08

2. Recent dynamics in Neisseria gonorrhoeae genomic epidemiology in Brazil: antimicrobial resistance and genomic lineages in 2017–20 compared to 2015–16;Journal of Antimicrobial Chemotherapy;2024-03-22

3. Antimicrobial treatment and resistance in sexually transmitted bacterial infections;Nature Reviews Microbiology;2024-03-20

4. Analytical and clinical validation of a multiplex PCR assay for detection of Neisseria gonorrhoeae and Chlamydia trachomatis including simultaneous LGV serotyping on an automated high-throughput PCR system;Microbiology Spectrum;2024-03-05

5. Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model;Frontiers in Pharmacology;2023-12-07