Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017-Reference-Cited by-同舟云学术

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

Published:2017-10-19 Issue:42 Volume:22 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Terkelsen David¹²,Tolstrup Jacob³¹,Johnsen Camilla Hundahl⁴,Lund Ole⁴,Larsen Helle Kiellberg³,Worning Peder²,Unemo Magnus⁵⁶,Westh Henrik⁵⁷²

Affiliation:

1. These authors contributed equally to the work

2. Department of Clinical Microbiology, Hvidovre Hospital, Copenhagen, Denmark

3. Department of Dermatovenerology, Bispebjerg Hospital, Copenhagen, Denmark

4. Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark

5. These authors share last authorship

6. WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

7. Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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