Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Author:

Piralla Antonio12ORCID,Borghesi Alessandro13ORCID,Di Comite Amelia3,Giardina Federica4,Ferrari Guglielmo2,Zanette Simona3,Figar Tiziana Angelica3,Angelini Micol3,Pisoni Camilla3,Pitrolo Antonino Maria Guglielmo2,Paolucci Stefania2,Rovida Francesca42,Pellicioli Isabella5,Bonanomi Ezio5,Baldanti Fausto642,Ghirardello Stefano63

Affiliation:

1. These authors contributed equally to this work and share first authorship

2. Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

3. Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

4. Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy

5. Paediatric Intensive Care Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy

6. These authors contributed equally to the work and share the last authorship

Abstract

Echovirus 11 (E11) has recently been associated with a series of nine neonatal cases of severe hepatitis in France. Here, we present severe hepatitis caused by E11 in a pair of twins. In one of the neonates, the clinical picture evolved to fulminant hepatitis. The E11 genome showed 99% nucleotide identity with E11 strains reported in the cases in France. Rapid genome characterisation using next generation sequencing is essential to identify new and more pathogenetic variants.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference10 articles.

1. World Health Organization (WHO). Enterovirus infection – France. Geneva: WHO; 2023Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON469

2. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023.;Grapin;Euro Surveill,2023

3. European Centre for Disease Prevention and Control (ECDC). Weekly bulletin. Communicable Disease Threats Report. Week 18, 30 April–6 May 2023. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-30-april-6-may-2023-week-18

4. Two years of viral metagenomics in a tertiary diagnostics unit: evaluation of the first 105 cases.;Kufner;Genes (Basel),2019

5. INSaFLU: an automated open web-based bioinformatics suite "from-reads" for influenza whole-genome-sequencing-based surveillance.;Borges;Genome Med,2018

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