Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Author:

Grapin Mathilde12,Mirand Audrey134,Pinquier Didier5,Basset Aurélie6,Bendavid Matthieu2,Bisseux Maxime34,Jeannoël Marion7,Kireche Bérengère8,Kossorotoff Manoelle9,L’Honneur Anne-Sophie10,Robin Lila8,Ville Yves11,Renolleau Sylvain2,Lemee Véronique12,Jarreau Pierre-Henri6,Desguerre Isabelle9,Lacaille Florence13,Leruez-Ville Marianne14,Guillaume Clémence15,Henquell Cécile34,Lapillonne Alexandre16,Schuffenecker Isabelle177,Aubart Mélodie17189ORCID

Affiliation:

1. These authors contributed equally to the work and share the first authorship.

2. Paediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

3. Auvergne University, LMGE UMR CNRS 6023, Team Epidemiology and pathophysiology of enterovirus Infection, Clermont-Ferrand, France

4. Clermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France

5. Neonatal and Paediatric Intensive Care Units, Rouen University Hospital, Rouen, France

6. Neonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

7. Hospices Civils de Lyon, Virology Department, French Reference Centre for enteroviruses and parechoviruses, associated laboratory, Lyon, France

8. Neonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France

9. Paediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

10. Virology laboratory, Cochin University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

11. Obstetrics and Fetal Medicine Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

12. Virology Department, Rouen University Hospital, Rouen, France

13. Pediatric Gastroenterology-Hepatology-Nutrition Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, University of Paris, Paris, France

14. Clinical Microbiology laboratory and Virology unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

15. Orléans Hospital, Microbiology laboratory, Orléans, France

16. Neonatal Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France

17. These authors contributed equally to the work and share the last authorship.

18. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Institut National de la Santé et de la Recherche Médicale U1163, Paris, France

Abstract

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3–5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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