Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022-Reference-Cited by-同舟云学术

Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022

Published:2023-03-09 Issue:10 Volume:28 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Golparian Daniel¹,Vestberg Nora²,Södersten Wiktor³,Jacobsson Susanne¹,Ohnishi Makoto⁴,Fang Hong²,Bhattarai Karin Haij²,Unemo Magnus⁵¹^ORCID

Affiliation:

1. WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro, Sweden

2. Department of Clinical Microbiology, Karolinska University Hospital, Huddinge, Sweden

3. Department of Venerology at Karolinska University Hospital, Stockholm, Sweden

4. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

5. Institute for Global Health, University College London (UCL), London, United Kingdom

Abstract

We report a ceftriaxone-resistant, multidrug-resistant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic penA-60.001. The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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