Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial-Reference-Cited by-同舟云学术

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Published:2023-01-03 Issue:1 Volume:329 Page:39
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

,Florescu Simin ¹,Stanciu Delia¹,Zaharia Mihaela ¹,Kosa Alma¹,Codreanu Daniel¹,Kidwai Aneela¹,Masood Sobia¹,Kaye Callum¹,Coutts Amanda¹,MacKay Lynn¹,Summers Charlotte¹,Polgarova Petra ¹,Farahi Neda¹,Fox Eleonore¹,McWilliam Stephen¹,Hawcutt Daniel¹,Rad Laura¹,O’Malley Laura¹,Whitbread Jennifer¹,Jones Dawn¹,Dore Rachael¹,Saunderson Paula ¹,Kelsall Olivia¹,Cowley Nicholas¹,Wild Laura¹,Thrush Jessica¹,Wood Hannah¹,Austin Karen¹,Bélteczki János¹,Magyar István¹,Fazekas Ágnes¹,Kovács Sándor¹,Szőke Viktória¹,Donnelly Adrian¹,Kelly Martin¹,Smyth Naoise¹,O’Kane Sinéad¹,McClintock Declan¹,Warnock Majella¹,Campbell Ryan ¹,McCallion Edmund¹, Azaiz Amine¹,Charron Cyril¹,Godement Mathieu¹,Geri Guillaume¹,Vieillard-Baron Antoine¹,Johnson Paul¹,McKenna Shirley¹,Hanley Joanne¹,Currie Andrew¹,Allen Barbara¹,McGoldrick Clare ¹,McMaster Moyra¹,Mani Ashwin¹,Mathew Meghena¹,Kandeepan Revathi¹,Vignesh C¹,TV Bharath¹,Ramakrishnan N¹,James Augustian ¹,Elvira Evangeline¹,Jayakumar Devachandran¹,Pratheema Ramachandran¹,Babu Suresh¹,Ebenezer R¹,Krishnaoorthy S¹,Ranganathan Lakshmi¹,Ganesan Manisha¹,Shree Madhu¹,Guilder Eileen¹,Butler Magdalena¹,Cowdrey Keri-Anne¹,Robertson Melissa¹,Ali Farisha¹,McMahon Ellie¹,Duffy Eamon¹,Chen Yan¹,Simmonds Catherine¹,McConnochie Rachael¹,O’Connor Caroline¹,El-Khawas Khaled¹,Richardson Angus¹,Hill Dianne¹,Commons Robert¹,Abdelkharim Hussam¹,Saxena Manoj¹,Muteithia Margaret¹,Dobell-Brown Kelsey¹,Jha Rajeev¹,Kalogirou Michael¹,Ellis Christine¹,Krishnamurthy Vinodh¹,O’Connor Aibhilin¹,Thurairatnam Saranya¹,Mukherjee Dipak¹,Kaliappan Agilan¹,Vertue Mark¹,Nicholson Anne¹,Riches Joanne¹,Maloney Gracie¹,Kittridge Lauren¹,Solesbury Amanda¹,Ramos Angelo¹,Collins Daniel¹,Brickell Kathy¹,Reid Liadain¹,Smyth Michelle¹,Breen Patrick¹,Spain Sandra¹,Curley Gerard¹,McEvoy Natalie¹,Geoghegan Pierce¹,Clarke Jennifer¹,Silversides Jon¹,McGuigan Peter¹,Ward Kathryn¹,O’Neill Aisling¹,Finn Stephanie¹,Wright Chris¹,Green Jackie¹,Collins Érin¹,Knott Cameron¹,Smith Julie¹,Boschert Catherine¹,Slieker Kitty¹,Ewalds Esther¹,Sanders Arnate¹,Wittenberg Wendy¹,Geurts Heidi¹,Poojara Latesh¹,Sara Treena¹,Nand Kiran¹,Reeve Brenda¹,Dechert William¹,Phillips Barbara ¹,Oritz-Ruiz de Gordoa Laura¹,Affleck Julia¹,Shaikh Arif¹,Murray Andrew¹,Ramanan Mahesh¹,Frakking Thuy¹,Pinnell Jez¹,Robinson Matt ¹,Gledhill Lisa¹,Wood Tracy¹,Sanghavi Ritesh¹,Bhonagiri Deepak¹,Ford Megan¹,Parikh Harshel G.¹,Avard Bronwyn¹,Nourse Mary¹,McDonald Bree¹,Edmunds Natasha¹,Hoiting Oscar¹,Peters Marco¹,Rengers Els¹,Evers Mirjam¹,Prinssen Anton¹,Morgan Matt¹,Cole Jade ¹,Hill Helen¹,Davies Michelle¹,Williams Angharad ¹,Thomas Emma¹,Davies Rhys¹,Wise Matt¹,Grimm Patrick¹,Soukup Jens¹,Wetzold Richard¹,Löbel Madlen¹,Starke Lisa¹,Lellouche Francois ¹,Lizotte Patricia¹,Declerq Pierre¹,Antoine Marchalot ¹,Stephanie Gelinotte¹,Jean-Pierre Eraldi¹,François Bourgerol ¹,Marion Beuzelin ¹,Philippe Rigaud¹,Pourcine Franck¹,Monchi Mehran¹,Luis David¹,Mercier Romain¹,Sagnier Anne¹,Verrier Nathalie¹,Caplin Cecile¹,Richecoeu Jack¹,Combaux Daniele¹,Siami Shidasp¹,Aparicio Christelle¹,Vautier Sarah¹,Jeblaoui Asma¹,Lemaire-Brunel Delphine¹,D'Aragon Frédérick¹,Carbonneau Elaine¹,Leblond Julie¹,Plantefeve Gaetan ¹,Leparco Cécile¹,Contou Damien¹,Fartoukh Muriel¹,Courtin Laura¹,Labbe Vincent¹,Voiriot Guillaume¹,Salhi Sara¹,Chassé Michaël¹,Carrier François¹,Boumahni Dounia ¹,Benettaib Fatna¹,Ghamraoui Ali¹,Sement Arnaud¹,Gachet Alexandre¹,Hanisch Alexis¹,Haffiane Abdelmagid¹,Boivin Anne-Hélène¹,Barreau Amelie¹,Guerineau Elodie¹,Poupblanc Séverine¹,Egreteau Pierre¹,Lefevre Montaine¹,Bocher Simon¹,Le Loup Guillaume¹,Le Guen Lenaïg¹,Carn Vanessa¹,Bertel Melanie¹,Antcliffe David¹,Templeton Maie ¹,Rojo Roceld¹,Coghlan Phoebe¹,Smee Joanna ¹,Barker Gareth¹,Finn André¹,Kreb Gabriele¹,Hoff Uwe¹,Hinrichs Carl¹,Nee Jens¹,Mackay Euan ¹,Cort Jon¹,Whileman Amanda¹,Spencer Thomas¹,Spittle Nick¹,Beavis Sarah¹,Padmakumar Anand¹,Dale Katie¹,Hawes Joanne¹,Moakes Emma¹,Gascoyne Rachel ¹,Pritchard Kelly¹,Stevenson Lesley¹,Cooke Justin¹,Nemeth-Roszpopa Karolina¹,Gauli Basanta¹,Bastola Sirjana¹,Muller Grégoire¹,Nay Mai-Anh¹,Kamel Toufik¹,Benzekri Dalila¹,Jacquier Sophie¹,Runge Isabelle¹,Mathonnet Armelle¹,Barbier François¹,Bretagnol Anne¹,Carter Jay¹,Van Der Heyden Kymbalee¹,Mehrtens Jan¹,Morris Anna¹,Morgan Stacey¹,Burke Tara¹,Mercier Emmanuelle¹,Chartier Delphine¹,Salmon Charlotte¹,Dequin Pierre-François¹,Garot Denis¹,Bellemare David¹,Cloutier Ève ¹,Daher Rana ¹,Costerousse Olivier¹,Boulanger Marie-Claude¹,Couillard-Chénard Émilie¹,Lauzier François¹,Francoeur Charles¹,Francois Bruno¹,Gay Alexandra¹,Anne-Laure Fedou¹,Ramali Mohamed¹,HC Ooi¹,Ghosh Alison¹,Osagie Rawlings¹,Arachchige Malka¹,Hartley Melissa¹,Cheung Winston¹,Wong Helen¹,Seigne Patrick¹,Eustace Joe¹,O'Callaghan Ann-Marie¹,O'Brien Fionnuala¹,Bamford Peter¹,Reid Andrew¹,Cawley Kathryn¹,Faulkner Maria¹,Pickering Charlotte¹,Raj Ashok ¹,Tsinaslanidis Georgios¹,Khade Reena ¹,Agha Gloria¹,Sekiwala Rose¹,Smith Tim¹,Brewer Chris¹,Gregory Jane¹,Limb James¹,Cowton Amanda¹,O’Brien Julie¹,Postlethwaite Kelly¹,Malakouti Salim¹,Music Edvin¹,Ricketts Dan¹,King Andrew¹,Clermont Gilles¹,Bart Robert¹,Mayr Florian¹,Schoenling Andrew¹,Andreae Mark¹,Shetty Varun¹,Brant Emily¹,Malley Brian¹,Donadee Chenell¹,Sackrowitz Rachel¹,Weissman Alexandra¹,Yealy Donald¹,Barton David¹,Talia Nadine¹,Nikitas Nikitas¹,Wells Colin¹,Lankester Liana¹,McMillan Helen¹,van den Oever Huub¹,Kruisdijk-Gerritsen Arriette¹,Haidar Ghady ¹,Bain William¹,Barbash Ian¹,Fitzpatrick Meghan¹,Franz Christopher¹,Kitsios Georgios¹,Moghbeli Kaveh¹,Rosborough Brian¹,Shah Faraaz¹,Suber Tomeka¹,Pulletz Mark¹,Williams Patricia¹,Birch Jenny¹,Wiseman Sophie¹,Horton Sarah¹,Alegria Ana¹,Turki Salah¹,Elsefi Tarek¹,Crisp Nikki¹,Allen Louise¹,Truman Nicholas¹,Smith Matthew¹,Chukkambotla Sri¹,Goddard Wendy¹,Duberley Stephen¹,Khan Meherunnisa¹,Kazi Aayesha¹,Simpson Joanna¹,Duke Graeme¹,Chan Peter¹,Carter Brittney¹,Hunter Stephanie¹,Voigt Ingo¹,Schueler Robert¹,Blank Elisabeth¹,Hüning Vanessa¹,Steffen Melanie¹,Goralski Patricia¹,Litton Ed¹,Regli Adrian¹,Pellicano Susan¹,Palermo Annamaria¹,Eroglu Ege¹,Bihari Shailesh¹,Laver Russell D.¹,Jin Xia¹,Brown Julia¹,McIntyre Joanne¹,French Craig¹,Bates Samantha¹,Towns Miriam¹,Yang Yang¹,McGain Forbes¹,McCullagh Iain¹,Cairns Tom¹,Hanson Helen¹,Patel Bijal¹,Clement Ian¹,Evetts George¹,Touma Omar ¹,Holland Susan¹,Hodge Christopher¹,Taylor Holly¹,Alderman Meera¹,Barnes Nicky¹,Da Rocha Joana¹,Smith Catherine¹,Brooks Nicole¹,Weerasinghe Thanuja¹,Sinclair Julie-Ann¹,Abusamra Yousuf¹,Doherty Ronan¹,Cudlipp Joanna ¹,Singh Rajeev¹,Yu Haili¹,Daebis Admad ¹,Ng Christopher¹,Kendrick Sara ¹,Saran Anita¹,Makky Ahmed ¹,Greener Danni¹,Rowe-Leete Louise¹,Edwards Alexandra¹,Bland Yvonne¹,Dolman Rozzie¹,Foster Tracy¹,Laffey John¹,McNicholas Bairbre¹,Scully Michael¹,Casey Siobhan ¹,Kernan Maeve¹,Brennan Aoife¹,Rangan Ritika¹,Tully Riona¹,Corbett Sarah¹,McCarthy Aine ¹,Duffy Oscar¹,Burke David¹,Linnett Vanessa¹,Sanderson Amanda¹,Ritzema Jenny¹,Wild Helen¹,Lucas Rachael¹,Marriott Yvonne¹,Andric Zdravko¹,Cviljevic Sabina¹,Br Renata¹,Zapalac Marija¹,Mirković Gordan¹,Khare Divya¹,Pinder Meredith¹,Gopinath Amitha ¹,Kannan Thogulava¹,Dean Steven¹,Vanmali Piyush¹,Depuydt Pieter¹,De Waele Jan¹,De Bus Liesbet¹,Fierens Jan¹,Bracke Stephanie¹,Vermassen Joris¹,Vermeiren Daisy¹,Pugh Richard¹,Lean Richard¹,Qiu Xinyi¹,Scanlan Jeremy¹,Evans Andrew¹,Davies Gwyneth¹,Lewis Joanne¹,Plesnikova Yvonna¹,Khoud Ahmed¹,Coetzee Samantha¹,Puxty Kathryn¹,Cathcart Susanne¹,Rimmer Dominic¹,Bagot Catherine¹,Scott Kathryn¹,Martin Laila¹,Yusuff Hakeem¹,Isgro Graziella¹,Brightling Chris¹,Bourne Michelle¹,Craner Michelle¹,Boyles Rebecca¹,Alexander Brian¹,Roberts Tracey¹,Nelli Apoorva¹,Rosenstein-Sisson Rachel¹,Speyer Rebecca¹,Pech Yadira¹,McCullough James¹,Tallott Mandy¹,Vazquez-Grande Gloria¹,Marten Nicole¹,Liu Theresa¹,Siddiqui Atif¹,Khanal Sushil¹,Amatya Sameena¹,Szakmany Tamas ¹,Cherian Shiney¹,Williams Gemma¹,James Christie¹,Waters Abby¹,Prout Rachel¹,Stedman Roger¹,Davies Louisa¹,Pegler Suzannah¹,Kyeremeh Lynsey¹,Moorhouse Louise¹,Arbane Gill¹,Marotti Marina¹,Bociek Aneta¹,Campos Sara¹,van Nieuwkoop Kees¹,Ottens Thomas¹,Visser Yorik¹,van den Berg Lettie ¹,van der Kraan-Donker Annemarie¹,Brett Stephen¹,Arias Sonia ¹,Hall Rebecca¹,Paneru Hem¹,Koirala Sabin¹,Paudel Pratibha¹,Wilson Maggie¹,Vaara Suvi¹,Pettilä Leena¹,Heinonen Jonna¹,Pettilä Ville¹,Jain Susan¹,Gupta Abhinav¹,Holbrook Catherine ¹,Antoine Pierre¹,Meziani Ferhat¹,Allam Hayat¹,Cattelan Jessy¹,Clere-Jehl Raphael¹,Helms Julie¹,Kummerlen Christine¹,Merdji Hamid¹,Monnier Alexandra¹,Rahmani Hassene¹,Studer Antoine¹,Schneider Francis¹,Castelain Vincent¹,Morel Guillaume¹,L’Hotellier Sylvie¹,Ochin Evelina¹,Vanjak Christian¹,Rouge Patrick¹,Bendjemar Lynda¹,Albert Martin¹,Serri Karim¹,Cavayas Alexandros¹,Duplaix Mathilde¹,Williams Virginie¹,Catorze Nuno José Teodoro Amaro dos Santos¹,Pereira Tiago Nuno Alfaro Lima¹,Ferreira Ricardo Manuel Castro¹,Bastos Joana Margarida Pereira Sousa¹,Batista Teresa Margarida Oliveira¹,Badie Julio¹,Berdaguer Fernando¹,Malfroy Sylvain¹,Mezher Chaouki¹,Bourgoin Charlotte¹,Moneger Guy¹,Bouvier Elodie¹,Muñoz-Bermúdez Rosana¹,Marin-Corral Judith¹,Degracia Anna¹,Gómez Francisco¹,López Maria¹,Aceto Romina¹,Aghemo Alessio¹,Badalamenti Salvatore¹,Brunetta Enrico¹,Cecconi Maurizio¹,Ciccarelli Michele¹,Constantini Elena¹,Greco Massimiliano¹,Folci Marco¹,Selmi Carlo¹,Voza Antonio¹,Henning Jeremy¹,Bonner Stephen¹,Hugill Keith¹,Cirstea Emanuel ¹,Wilkinson Dean¹,Jones Jessica¹,Altomy Mohammed¹,Karlikowski Michal¹,Sutherland Helen¹,Wilhelmsen Elva¹,Woods Jane¹,North Julie¹,Pletz Mathias¹,Hagel Stefan¹,Ankert Juliane¹,Kolanos Steffi¹,Bloos Frank¹,Simons Koen¹,van Zuylen Tamara¹,Bouman Angela¹,Kumar Nikhil¹,Panwar Rakshit¹,Poulter Amber-Louise¹,Sunkara Krishna¹,Szigligeti Gábor¹,Leszkoven János¹,Rochwerg Bram¹,Karachi Tim¹,Oczkowski Simon¹,Centofanti John¹,Millen Tina¹,Sundaran Dhinesh¹,Hollos Laszlo¹,Williams Anna¹,Turns Margaret ¹,Walsh Joanne ¹,Al Qasim Eman¹,Alswaidan Lolowa¹,Hegazy Mohamed¹,Arishi Hatim¹,Al Amri Ali¹,AlQahtani Samah¹,Naidu Brintha¹,Tlayjeh Haytham¹,Hussain Sajid¹,Al Enezi Farhan¹,Abdukahil Sheryl Ann¹,Hopkins Phil¹,Smith John¹,Noble Harriet ¹,O’Reilly Kevin¹,Mehta Reena¹,Wong Onyee ¹,Makanju Esther¹,Rao Deepak¹,Sikondari Nyma ¹,Saha Sian¹,Corcoran Ele¹,Pappa Evita¹,Cockrell Maeve¹,Donegan Clare¹,Balaie Morteza¹,Nickoleit-Bitzenberger Daniela¹,Schaaf Bernhard¹,Meermeier Werner¹,Prebeg Katharina¹,Azzaui Harun¹,Hower Martin¹,Brieger Klaus-Gerd¹,Elender Corinna¹,Sabelhaus Timo¹,Riepe Ansgar¹,Akamp Ceren¹,Kremling Julius¹,Klein Daniela¹,Landsiedel-Mechenbier Elke¹,Laha Shondipon¹,Verlander Mark¹,Williams Alexandra¹,Jha Avinash¹,Megarbane Bruno¹,Voicu Sebastian¹,Deye Nicolas¹,Malissin Isabelle¹,Sutterlin Laetitia¹,Mrad Aymen¹,Lehalleur Adrien¹,Naim Giulia¹,Nguyen Philippe¹,Ekhérian Jean-Michel¹,Boué Yvonnick¹,Sidéris Georgios¹,Vodovar Dominique¹,Guérin Emmanuelle¹,Grant Caroline¹,Brain Matthew¹,Mineall Sarah¹,Paramasivam Elankumaran¹,Wilby Elizabeth¹,Ogg Bethan¹,Howcroft Clare¹,Aspinwall Angelique¹,Charlton Sam¹,Gould Richard¹,Mistry Deena¹,Awan Sidra¹,Bedford Caroline¹,Carr-Wilkinson Joanne ¹,Hall Andrew¹,Cooke Jill¹,Gardiner-Hill Caroline¹,Maloney Carolyn¹,Brunskill Nigel¹,Watchorn Olivia¹,Hardy Chloe¹,Qureshi Hafiz¹,Flint Neil¹,Nicholson Sarah¹,Southin Sara¹,Nicholson Andrew¹,Ghattaoraya Amardeep¹,Harding Daniel¹,O’Halloran Sinead¹,Collins Amy¹,Smith Emma¹,Trues Estefania¹,Borgatta Barbara¹,Turner-Bone Ian¹,Reddy Amie¹,Wilding Laura¹,Wilson Craig¹,Surti Zuhra¹,Aneman Anders¹,Miller Jennene¹,White Hayden¹,Estensen Kristen¹,Morrison Lynette¹,Sutton Joanne¹,Cooper Melanie¹,Warnapura Loku¹,Agno Ronan¹,Sathianathan Prasannakumari ¹,Shaw Deborah¹,Ijaz Nazia¹,Spong Adam¹,Sabaretnam Suganya¹,Burns Dean¹,Lang Eva¹,Tate Margaret¹,Fischer Roy¹,Biradar Vishwanath¹,Soar Natalie¹,Golden David¹,Davey Miriam¹,Seaman Rebecca¹,Osborne Alexander¹,Bannard-Smith Jonathan¹,Clark Richard¹,Birchall Kathrine¹,Henry Joanne¹,Pomeroy Fiona¹,Quayle Rachael¹,Wylie Katharine¹,Sukuraman Anila¹,John Maya¹,Sibin Sindhu¹,Leditschke Anne¹,Finnis Mackenzie¹,Jongebloed Katherine¹,Khwaja Kosar¹,Campisi Josie¹,van Vonderen Marit¹,Pietersma Mario¹,Vrolijk Loes¹,Kampschreur Linda¹,van Gulik Laura¹,Makowski Arystarch¹,Misztal Beata¹,Haider Syeda¹,Liao Angela¹,Squires Rebecca¹,Oborska Aneta¹,Kayani Abdul¹,Kalchko-Veyssal Selver¹,Prabakaran Rajalakshmi¹,Hadebe Bernard¹,KalchkoVeyssal Selver¹,Williams Tony¹,Song Rima¹,Morpeth Susan¹,Lai Vivian¹,Habraken Hannah¹,Stewart Richard¹,Mwaura Esther¹,Mew Louise¹,Wren Lynn¹,Willams Felicity¹,Sutherland Sara-Beth¹,Rebello Rashmi¹,Shehabi Yahya¹,Al-Bassam Wisam¹,Hulley Amanda¹,Kadam Umesh¹,Sathianathan Kushaharan¹,Innes Richard¹,Doble Patricia¹,Graham Libby¹,Shovelton Charmaine¹,Dean Tessa¹,Salahuddin Nawal¹,Aryal Diptesh¹,Koirala Kanchan¹,Rai Namrata¹,Luitel Subekshya¹,Seppelt Ian¹,Whitehead Christina¹,Lowrey Julie¹,Gresham Rebecca¹,Masters Kristy¹,Hamlyn Vincent¹,Hawkins Nancy¹,Roynon-Reed Anna¹,Cutler Sean¹,Lewis Sarah¹,Lazaro Juan¹,Newman Tabitha¹,Aravindan Latha¹,Asghar Adeeba¹,Bartholomew Jazz¹,Bayne Madeleine¹,Beddows Seonaid¹,Birch Catherine¹,Brend Morwenna¹,Byrne Rahim¹,Campbell Debbie¹,Campbell Hilary¹,Chambers Emma¹,Clinton Alison¹,Collins Joanne¹,Crawshaw Sarah¹,Dawson Laura Ann¹,Donaldson Kate¹,Drake Chelsea¹,Dyas Sarah¹,Ellis Yvette¹,Gilmour Kate¹,Goodwin Jayne¹,Halden Sandra¹,Hall Alistair S¹,Hanson Jane¹,Harper Heather¹,Harrison Susan¹,Hayes Amber¹,Hodgson Helen¹,Hurford Sally-Anne¹,Jackson Shane¹,Levett Chris¹,Lock Stephen¹,Lockett Teresa¹,Logan Meg¹,Lomme Kaatje¹,Luo Ji¹,Marsh Emma¹,McKenna Sonia¹,Mguni Nhlanhla¹,Monaghan Holly¹,Murphy Sheenagh¹,Muzengi Natasha¹,Naz Mobeena¹,O'Kell Eleanor¹,Oliver Anne¹,O'Reilly Joanna¹,Pearson Karen¹,Porter David¹,Potter Alison¹,Rook Clare¹,Rounds Charles¹,Sheffield Jonathan¹,Shirley Kim¹,Siewersk Chris¹,Skinner Tabitha¹,Speight Holly¹,Sutu Mihaela¹,Unsworth Adam¹,Van’t Hoff William¹,Walker Susan¹,Williams Hannah¹,Williams Penny¹,Williamson Dawn¹,Williamson James D¹,Duan Erick¹,Tsang Jennifer¹,Patterson Lisa¹,Austin Pauline¹,Chapman Susan¹,Cabrelli Louise¹,Fletcher Simon¹,Nortje Jurgens¹,Fottrell-Gould Deirdre¹,Randell Georgina¹,Stammers Katie¹,Healey Gail¹,Pinto Marta¹,Borrill Zoe¹,Duncan Tracy¹,Ustianowski Andrew¹,Uriel Alison¹,Eltayeb Ayaa¹,Alfonso Jordan¹,Hey Samuel¹,Shaw Joanne¹,Fox Claire¹,Lindergard Gabriella¹,Charles Bethan¹,Blackledge Bethany¹,Connolly Karen¹,Harris Jade¹,Cuesta Jeronimo¹,Xavier Kugan¹,Purohit Dharam¹,Elhassan Munzir¹,Haldeos Anne¹,Vincent Rachel¹,Abdelrazik Marwa¹,Jenkins Samuel¹,Ganesan Arunkumar¹,Kumar Rohit¹,Carter David¹,Bakthavatsalam Dhanalakshmi¹,Frater Alasdair¹,Saleem Malik¹,Everitt Robert¹,Hacking Danielle¹,Zaman Mohsin¹,Elmahi Einas¹,Jones Andrea¹,Hall Kathryn¹,Phillips Matt¹,Terrill Lenae¹,Mills Gary¹,Raithatha Ajay¹,Bauchmuller Kris¹,Ryalls Kim¹,Harrington Kate¹,Bowler Helen¹,Sall Jas¹,Bourne Richard¹,Gross Jamie¹,Massey Natalie¹,Adebambo Olumide¹,Long Matilda¹,Tony Kiran¹,Juffermans Nicole¹,Koopmans Matty¹,Dujardin Romein¹,Alderink Bashar¹,Rowland Matthew¹,Hutton Paula¹,Bashyal Archana¹,Davidson Neil¹,Hird Clare¹,Chhablani Manish¹,Phalod Gunjan¹,Kirkby Amy¹,Archer Simon¹,Netherton Kimberley ¹,Reschreiter Henrik¹,Camsooksai Julie¹,Patch Sarah¹,Jenkins Sarah¹,Humphrey Charlotte¹,Flynn Gordon¹,Harrington Claire¹,Kruger Peter¹,Walsham James¹,Meyer Jason¹,Harward Meg¹,Jones Cassie¹,Sathe Sonia¹,Roche Lisa¹,Davies Ellie¹,Skinner Denise¹,Gaylard Jane¹,Newman Julie¹,Pogson David¹,Rose Steve¹,Daly Zoe¹,Brimfield Lutece¹,Nown Angie¹,Parekh Dhruv¹,Bergin Colin¹,Bates Michelle¹,McGhee Christopher¹,Lynch Daniella¹,Bhandal Khushpreet¹,Tsakiridou Kyriaki¹,Bamford Amy¹,Cooper Lauren¹,Whitehouse Tony¹,Veenith Tonny¹,Forster Elliot¹,O'Connell Martin¹,Sim Malcolm¹,Hay Sophie¹,Henderson Steven¹,Nygren Maria¹,Valentine Eliza¹,Katary Amro¹,Bell Gillian¹,Wilcox Louise¹,Mataliotakis Michail¹,Smith Paul¹,Ali Murtaza¹,Isguzar Agah¹,Phull Mandeep-Kaur¹,Zaidi Abbas¹,Pogreban Tatiana¹,Rosaroso Lace¹,Harvey Daniel¹,Lowe Benjamin¹,Meredith Megan¹,Ryan Lucy¹,Schouten Jeroen¹,Pickkers Peter¹,Roovers Noortje¹,Klop-Riehl Margreet¹,van der Eng Hetty¹,Sloots-Cuppen Sonja¹,Preijers Lieke¹,van Oosten Nienke¹,Moine Pierre¹,Heming Nicholas¹,Maxime Virginie¹,Bossard Isabelle¹,Nicholier Tiphaine¹,Clair Bernard¹,Orlikowski David¹,Bounab Rania¹,Abdeladim Lilia¹,Baker Stuart¹,Duroux Maree¹,Ratcliffe Megan¹,Sy Eric¹,Mailman Jonathan¹,Lee Stephen¹,Gupta Chiraag¹,Kassir Sandy¹,López Rafael¹,Rodríguez-Gómez Jorge¹,Cárcel Sheila¹,Carmona Rosario¹,de la Fuente Carmen¹,Rodriguez Marina¹,Jan Hassing Robert ¹,Greven Frances¹,Huijbens Danique¹,Roebers L¹,Verheij Harald¹,Miles Helen¹,Attokaran Antony¹,Buehner Ulrike¹,Williams Erin¹,Chapman Marianne¹,O’Connor Stephanie¹,Glasby Kathleen¹,Rivett Justine¹,Brown Nerissa¹,Kutsogiannis Demetrios¹,Thompson Patricia¹,Rooney Kevin¹,Rodden Natalie¹,Thomson Nicola¹,McGlynn Deborah¹,Abel Lynn¹,Gemmell Lisa¹,Sundaram Radha¹,Hornsby James¹,Walden Andrew¹,Keating Liza¹,Frise Matthew¹,Rai Sabi¹,Bartley Shauna¹,Schuster-Bruce Martin¹,Pitts Sally¹,Miln Rebecca¹,Purandare Laura¹,Vamplew Luke¹,Patel Brijesh¹,Dempster Debra¹,Gummadi Mahitha¹,Dormand Natalie¹,Wang Shu¹,Spivey Michael¹,Bean Sarah¹,Burt Karen¹,Moore Lorraine¹,Hammonds Fiona¹,Richards Carol¹,Campbell Lewis¹,Smyth Kirsty¹,Day Christopher¹,Zitter Letizia¹,Benyon Sarah¹,Singh Jayaprakash¹,Lynch Ceri ¹,Mikusek Justyna¹,Deacon Bethan¹,Turner Keri¹,Baker Evelyn¹,Hickey John¹,Champanerkar Shreekant¹,Aitken Lindianne ¹,LewisProsser Lorraine¹,Ahmad Norfaizan ¹,Wiles Matt¹,Willson Jayne¹,Grecu Irina¹,Martin Jane¹,Wrey Brown Caroline¹,Arias Ana-Marie¹,Bevan Emily¹,Westlake Samantha¹,Craven Thomas¹,Hope David¹,Singleton Jo¹,Clark Sarah¹,McCulloch Corrienne¹,Biddie Simon¹,Welters Ingeborg¹,Hamilton David¹,Williams Karen¹,Waugh Victoria¹,Shaw David¹,Mulla Suleman¹,Waite Alicia¹,Roman Jaime¹,Martinez Maria¹,Johnston Brian¹,Puthucheary Zudin¹,Martin Timothy¹,Santos Filipa¹,Uddin Ruzena ¹,Fernandez Maria¹,Seidu Fatima¹,Somerville Alastair¹,Pakats Mari-Liis¹,Begum Salma¹,Shahid Tasnin ¹,Presneill Jeffrey¹,Barge Deborah¹,Byrne Kathleen¹,Janin Pierre¹,Yarad Elizabeth¹,Bass Frances¹,Hammond Naomi¹,O’Connor Anne¹,Vuylsteke Alain¹,Chan Charles¹,Victor Saji¹,Waterson Sharon¹,McNamara Robert¹,Boardman Melanie¹,Gattas David¹,Buhr Heidi¹,Coles Jennifer¹,Matsa Ramprasad¹,Gellamucho Minerva¹,Creagh-Brown Ben¹,Marriot Cheryl¹,Salberg Armorel¹,Zouita Louisa¹,Stone Sarah¹,Michalak Natalia¹,Donlon Sinead¹,Mtuwa Shelia¹,Mayangao Irving¹,Verula Jerik¹,Burda Dorota¹,Harris Celia¹,Jones Emily¹,Bradley Paul¹,Tarr Esther¹,Harden Lesley¹,Piercy Charlie¹,Nolan Jerry¹,Kerslake Ian¹,Cook Tim¹,Simpson Tom¹,Dalton James¹,Demetriou Carrie¹,Mitchard Sarah¹,Ramos Lidia¹,White Katie¹,Johnson Toby¹,Headdon William¹,Spencer Stephen¹,White Alison¹,Howie Lucy¹,Reay Michael¹,Jenkins Steve¹,Watts Angela¹,Traverse Eleanor¹,Jennings Stacey¹,Anumakonda Vikram¹,Tuckwell Caroline¹,Harrow Kath¹,Matthews Julie¹,McGarry Karen¹,Moore Vanessa¹,Smith Lucie¹,Summerfield Anna¹,Dark Paul¹,Harvey Alice¹,Doonan Reece¹,McMorrow Liam¹,Knowles Karen¹,Pendlebury Jessica¹,Lee Stephanie¹,Perez Jane¹,Marsden Tracy¹,Taylor Melanie¹,Michael Angiy ¹,Collis Matthew¹,Claxton Andrew¹,Habeichi Wadih¹,Horner Dan¹,Slaughter Melanie¹,Thomas Vicky¹,Proudfoot Nicola¹,Keatley Claire¹,Donnison Phil¹,Casey Ruth¹,Irving Ben¹,Matimba-Mupaya Wadzanai¹,Reed Catherine¹,Anthony Alpha¹,Trim Fiona¹,Cambalova Lenka¹,Robertson Debra¹,Wilson Anna¹,Hulme Jonathan¹,Kannan Santhana¹,Kinney Fiona¹,Senya Ho¹,Hayes Anne¹,Ratnam Valli¹,Gill Mandy¹,Kirk Jill¹,Shelton Sarah¹,Schweikert Sacha¹,Wibrow Bradley¹,Anstey Matthew¹,Rauniyar Rashmi¹,Khoso Nasir¹,Asif Namra¹,Taqdees Huda¹,Frey Christian¹,Scano Riccardo¹,McKee Madeleine¹,Murphy Peter¹,Thomas Matt¹,Worner Ruth¹,Faulkner Beverley¹,Gendall Emma¹,Hayes Kati¹,Blakemore Hayley¹,Borislavova Borislava¹,Deshpande Kush¹,van Haren Frank¹,Konecny Pam¹,Inskip Deborah¹,Tung Raymond¹,Hayes Leanne¹,Murphy Lorna¹,Neill Andy¹,Reidy Bryan¹,O’Dwyer Michael¹,Ryan Donal¹,Ainscough Kate¹,Hamilton-Davies Colin¹,Chan Carmen¹,Mfuko Celina¹,Abbass Hakam¹,Mandadapu Vineela¹,Leaver Susannah¹,Patel Kamal¹,Farnell-Ward Sarah¹,Saluzzio Romina¹,Rawlins Sam¹,Sicat Christine¹,De Keulenaer Bart¹,Ferrier Janet¹,Fysh Ed¹,Davda Ashish¹,Mevavala Bhaumik¹,Cook Deborah¹,Clarke Frances¹,Banach Dorota¹,Fernández de Pinedo Artaraz Ziortza ¹,Cabreros Leilani¹,Latham Victoria¹,Kruisselbrink Rebecca¹,Brochard Laurent¹,Burns Karen¹,Sandhu Gyan¹,Khalid Imrana¹,White Ian¹,Croft Maria¹,Holland Nicky¹,Pereira Rita¹,Nair Priya¹,Buscher Hergen¹,Reynolds Claire¹,Newman Sally¹,Santamaria John¹,Barbazza Leanne¹,Homes Jennifer¹,Smith Roger¹,Zaki Ahmed¹,Johnson David¹,Garrard Hywel¹,Juhaz Vera¹,Brown Louise¹,Pemberton Abigail¹,Roy Alistair¹,Rostron Anthony¹,Woods Lindsey¹,Cornell Sarah¹,Fowler Rob¹,Adhikari Neill¹,Kamra Maneesha¹,Marinoff Nicole¹,Garrett Peter¹,Murray Lauren¹,Brailsford Jane¹,Fennessy Gerard¹,Mulder John¹,Morgan Rebecca¹,Pillai Suresh¹,Harford Rachel¹,Ivatt Helen¹,Evans Debra¹,Richards Suzanne¹,Roberts Eilir¹,Bowen James¹,Ainsworth James¹,Kuitunen Anne¹,Karlsson Sari¹,Vahtera Annukka¹,Kiiski Heikki¹,Ristimäki Sanna¹,Albrett Jonathan¹,Jackson Carolyn¹,Kirkham Simon¹,Tamme Kadri¹,Reinhard Veronika¹,Ellervee Anneli¹,Põldots Liisi¹,Rennit Pille¹,Svitškar Nikolai¹,Browne Troy¹,Grimwade Kate¹,Goodson Jennifer¹,Keet Owen¹,Callender Owen¹,Udy Andrew¹,McCracken Phoebe¹,Young Meredith¹,Board Jasmin¹,Martin Emma¹,Kasipandian Vidya¹,Patel Amit¹,Allibone Suzanne¹,Mary-Genetu Roman¹,English Shane¹,Watpool Irene¹,Porteous Rebecca¹,Miezitis Sydney¹,McIntyre Lauralyn¹,Brady Kara¹,Vale Cassandra¹,Shekar Kiran¹,Lavana Jayshree¹,Parmar Dinesh¹,Peake Sandra¹,Kurenda Catherine¹,Hormis Anil¹,Walker Rachel¹,Collier Dawn¹,Kimpton Sarah¹,Oakley Susan¹,Bhagani Sanjay¹,De Neef Mark¹,Garcia Sara¹,Maharajh Amitaa ¹,Nandani Aarti¹,Dobson Jade¹,Fernando Gloria¹,Eastgate Christine¹,Gomez Keith¹,Abdi Zakee¹,Tatham Kate¹,Jhanji Shaman¹,Black Ethel¹,Dela Rosa Arnold¹,Howle Ryan¹,Baikady Ravishankar¹,Tully Redmond¹,Drummond Andrew¹,Dearden Joy¹,Philbin Jennifer¹,Munt Sheila¹,Gopal Shameer¹,Pooni Jagtar- Singh¹,Ganguly Saibal¹,Smallwood Andrew¹,Metherell Stella¹,Naeem Anas¹,Fagan Laura¹,Ryan Emily¹,Mariappa Vasanth¹,Smith Judith¹,Foulds Angela¹,Revill Adam¹,Bhattarai Binita¹,de Jonge Evert¹,Wigbers Jeanette¹,del Prado Michael¹,Cremer Olaf¹,Mulier Jelle¹,Peters Anna¹,Romberg Birgit¹,Schutgens Roger¹,Troeman Darren¹,van Opdorp Marjolein¹,Besten Henny¹,Brakké Karen¹,Barber Russell¹,Hilldrith Anette¹,Kluge Stefan¹,Nierhaus Axel¹,Jarczak Dominik¹,Roedl Kevin¹,Kochanek Matthias¹,Rueß-Paterno Giusi¹,Mc-Kenzie Josette¹,Eichenauer Dennis¹,Shimabukuro-Vornhagen Alexander¹,Wilcox Elizabeth¹,del Sorbo Lorenzo¹,Abdelhady Hesham¹,Romagnuolo Tina¹,Simpson Scott¹,Maiden Matthew¹,Horton Michelle¹,Trickey Jemma¹,Krajinovic Vladimir¹,Kutleša Marko¹,Kotarski Viktor¹,Brohi Farooq¹,Jagannathan Vijay¹,Clark Michele¹,Purvis Sarah¹,Wetherill Bill¹,Brajković Ana¹,Babel Jakša¹,Sever Helena¹,Dragija Lidija¹,Kušan Ira¹,Dushianthan Ahilanandan ¹,Cusack Rebecca¹,de Courcy-Golder Kim¹,Salmon Karen¹,Burnish Rachel¹,Smith Simon¹,Jackson Susan¹,Ruiz Winningtom ¹,Duke Zoe¹,Johns Magaret ¹,Male Michelle¹,Gladas Kirsty¹,Virdee Satwinder ¹,Swabe Jacqueline¹,Tomlinson Helen¹,Rohde Gernot¹,Grünewaldt Achim¹,Bojunga Jörg¹,Petros Sirak¹,Kunz Kevin¹,Schütze Bianka¹,Weismann Dirk¹,Frey Anna¹,Drayss Maria¹,Goebeler M.E.¹,Flor Thomas¹,Fragner Gertrud¹,Wahl Nadine¹,Totzke Juliane¹,Sayehli Cyrus¹,Hakak Sheeba¹,Altaf Wahid¹,O'Sullivan Mike¹,Murphy Aisling¹,Walsh Leo¹,Rega La Valle Antonio¹,Bewley Jeremy¹,Sweet Katie¹,Grimmer Lisa¹,Johnson Rebekah¹,Wyatt Rachel¹,Morgan Karen¹,Varghese Siby¹,Willis Joanna¹,Stratton Emma¹,Kyle Laura¹,Putensen Daniel¹,Drury Kay¹,Skorko Agnieszka¹,Bremmer Pamela¹,Ward Geraldine¹,Bassford Christopher¹,Sligl Wendy¹,Baig Nadia¹,Rewa Oleksa¹,Bagshaw Sean¹,Basile Kim¹,Stavor Dara¹,Burbee Dylan¹,McNamara Amanda¹,Wunderley Renee¹,Bensen Nicole¹,Richardson Aaron¹,Adams Peter¹,Vita Tina¹,Buhay Megan¹,Scholl Denise¹,Gilliam Matthew¹,Winters James¹,Doherty Kaleigh¹,Berryman Emily¹,Ghaffari Mehrdad¹,Marroquin Oscar¹,Quinn Kevin¹,Garrard William¹,Kalchthaler Kyle¹,Beard Gregory¹,Skrtich Aimee¹,Bagavathy Kavitha¹,Drapola Debra¹,Bryan-Morris Kayla¹,Arnold John¹,Reynolds Bob¹,Hussain Mahwish¹,Dunsavage Janice¹,Saiyed Salim¹,Hernandez Erik¹,Goldman John¹,Brown Cynthia¹,Comp Susan¹,Raczek James¹,Morris Jenny¹,Vargas Jr. Jesus¹,Weiss Daniel¹,Hensley Joseph¹,Kochert Erik¹,Wnuk Chris¹,Nemeth Christopher¹,Mowery Brent¹,Hutchinson Christina¹,Winters Lauren¹,McAdams David¹,Walker Gena¹,Minnier Tami¹,Wisniewski Mary¹,Mayak Katelyn¹,McCreary Erin¹,Martin Elise¹,Bariola Ryan¹,Viehman Alex¹,Daley Jessica¹,Lopus Alyssa¹,Schmidhofer Mark¹,Ambrosino Richard¹,Keen Sherbrina ¹,Toffalo Sue¹,Stambaugh Martha¹,Trimmer Ken¹,Perri Reno¹,Casali Sherry¹,Medva Rebecca¹,Massar Brent¹,Beyerl Ashley¹,Burkey Jason¹,Keeler Sheryl¹,Lowery Maryalyce¹,Oncea Lynne¹,Daugherty Jason¹,Sevilla Chanthou¹,Woelke Amy¹,Dice Julie¹,Weber Lisa¹,Roth Jason¹,Ferringer Cindy¹,Beer Deborah¹,Fesz Jessica¹,Carpio Lillian¹,Colin Gwenhael¹,Zinzoni Vanessa¹,Maquigneau Natacha¹,Henri-Lagarrigue Matthieu¹,Pouplet Caroline¹,Reill Lorenz¹,Distler Michael¹,Maselli Astrid¹,Martynoga Robert¹,Trask Kara¹,Butler Amelia¹,Attwood Ben¹,Parsons Penny¹,Campbell Bridget¹,Smith Alex¹,Page Valerie¹,Zhao Xiao¹,Oza Deepali¹,Abrahamson Gail¹,Sheath Ben¹,Ellis Chiara¹,Young Paul¹,Young Chelsea¹,Lesona Eden¹,Navarra Leanlove¹,Cruz Raulle¹,Delaney Kirsha¹,Cruz Rhoze¹,Aguilar-Dano April¹,Gojanovic Marlene¹,Rhodes Jonathan¹,Anderson Thomas¹,Morris Sheila¹,Nayyar Vineet¹,Bowen David¹,Kong Jing¹,Joy Jenyfer¹,Fuchs Ralph¹,Lambert Bridget¹,Tai Charlotte¹,Thomas Amy¹,Keen Alexandra¹,Tierney Carey¹,Omer Nimca¹,Bacon Gina¹,Tridente Ascanio¹,Shuker Karen¹,Anders Jeanette¹,Greer Sandra¹,Scott Paula¹,Millington Amy¹,Buchanan Philip¹,Kirk Jodie¹,Binnie Alexandra¹,Powell Elizabeth¹,McMillan Alexandra¹,Luk Tracy¹,Aref Noah¹,Denmade Craig¹,Sadera Girendra ¹,Jacob Reni¹,Jones Cathy¹,Hughes Debbie¹,Sterba Martin¹,Geng Wenli¹,Digby Stephen¹,Southern David¹,Reddy Harsha¹,Hulse Sarah¹,Campbell Andrew¹,Garton Mark¹,Watkins Claire¹,Smuts Sara¹,Quinn Alison¹,Simpson Benjamin¹,McMillan Catherine¹,Finch Cheryl¹,Hill Claire¹,Cooper Josh¹,Budd Joanna¹,Small Charlotte¹,O’Leary Ryan¹,Birch Janine¹,Collins Emma¹,Holland Andrew¹,Alexander Peter¹,Felton Tim¹,Ferguson Susan¹,Sellers Katharine¹,Ward Luke¹,Yates David¹,Birkinshaw Isobel¹,Kell Kay¹,Scott Zoe¹,Pearson Harriet¹,Hashmi Madiha¹,Ali Maryam¹,Hassan Noor¹,Panjwani Ashok¹,Umrani Zulfiqar¹,Shaikh Mohiuddin¹,Siddiqui Ayesha¹,Ain Quratul¹,Kanwal Darakhshan¹,van Bree Sjoerd¹,Bouw-Ruiter Marianne¹,Osinga Margreet¹, van Zanten Arthur¹,McEldrew Rebecca¹,Rashan Sumayyah¹,Singh Vanessa¹,Azergui Nora¹,Bari Sara¹,Beltran Mercedes¹,Brugman Curt¹,Groeneveld Erika¹,Jafarzadeh Mina¹,Keijzer-Timmers Nicole¹,Kester Esmee¹,Koelink Maaike¹,Kwakkenbos-Craanen Marion¹,Okundaye Clementina¹,Parker Lorraine¹,Peters Svenja¹,Post Sophie¹,Rietveld Ilse¹,Scheepstra-Beukers Irma¹,Schreuder Gerwin¹,Smit Albertine¹,Brillinger Nicole¹,Markgraf René¹,Eichinger Fred¹,Doran Peter¹,Anjum Aisha ¹,Best-Lane Janis¹,Barton Frances¹,Miller Lorna¹,Peters Sam¹,Richards-Belle Alvin¹,Saull Michelle¹,Sprinckmoller Stefan¹,Wiley Daisy¹,Darnell Robert¹,Au Carly¹,Lindstrum Kelsey¹,Cheng Allen¹,Forbes Andrew¹,Heritier Stephane¹,Trapani Tony¹,Cuthbertson Brian¹,Manoharan Venika¹,Dondrop Arjen¹,Jayakumar Deva¹,Tolppa Timo¹,Ehrmann Stephan¹,Hullegie Sebastiaan¹,Povoa Pedro¹,Beasley Richard¹,Daneman Nick¹,Fowler Robert¹,McGloughlin Steve¹,Paterson David¹,Venkatesh Bala¹,de Jong Menno¹,Uyeki Tim¹,Baillie Kenneth¹,Hashmi Madhia¹,Netea Mihai¹,Orr Katrina¹,Patanwala Asad¹,Tong Steve¹,Cooper Nichola¹,Galea James¹,Leavis Helen¹,Ogungbenro Kayode¹,Patawala Asad¹,Rademaker Emma¹,Tong Steven¹,Youngstein Taryn¹,Carrier Marc¹,Fergusson Dean¹,Hunt Beverley¹,Kumar Anand¹,Laffan Mike¹,Lother Sylvain¹,Middeldorp Saskia¹,Stanworth Simon¹,de Man Angelique¹,Masse Marie-Helene¹,Abraham Jacinta¹,Arnold Donald¹,Begin Phillipe¹,Charlewood Richard¹,Chasse Michael¹,Cooper Jamie¹,Coyne Mark¹,Daly James¹,Gosbell Iain¹,Harvala-Simmonds Heli¹,MacLennan Sheila¹,McDyer John¹,Menon David¹,Pridee Nicole¹,Roberts David¹,Thomas Helen¹,Tinmouth Alan¹,Triulzi Darrell¹,Walsh Tim¹,Wood Erica¹,Calfee Carolyn¹,O’Kane Cecilia¹,Shyamsundar Murali¹,Sinha Pratik¹,Thompson Taylor¹,Young Ian¹,Burrell Aidan¹,Ferguson Niall¹,Hodgson Carol¹,Orford Neil¹,Phua Jason¹,Baron Rebecca¹,Epelman Slava ¹,Frankfurter Claudia ¹,Gommans Frank ¹,Kim Edy¹,Leaf David ¹,Vaduganathan Muthiah¹,van Kimmenade Roland¹,Sanil Ashish¹,van Beurden Marloes¹,Effelaar Evelien¹,Schotsman Joost¹,Boyd Craig¹,Harland Cain¹,Shearer Audrey¹,Wren Jess¹,Clermont Giles¹,Ricketts Daniel¹,Attanayaka Udara¹,Darshana Sri¹,Ishani Pramodya¹,Udayanga Ishara ¹,Higgins Alisa M.²,Berry Lindsay R.³,Lorenzi Elizabeth³,Murthy Srinivas⁴,McQuilten Zoe²⁵,Mouncey Paul R.⁶,Al-Beidh Farah⁷,Annane Djillali⁸⁹,Arabi Yaseen M.¹⁰,Beane Abi¹¹,van Bentum-Puijk Wilma¹²,Bhimani Zahra¹³,Bonten Marc J. M.¹²,Bradbury Charlotte A.¹⁴,Brunkhorst Frank M.¹⁵,Burrell Aiden²,Buzgau Adrian²,Buxton Meredith¹⁶,Charles Walton N.⁶,Cove Matthew¹⁷,Detry Michelle A.³,Estcourt Lise J.¹⁸,Fagbodun Elizabeth O.⁷,Fitzgerald Mark³,Girard Timothy D.¹⁹,Goligher Ewan C.²⁰²¹,Goossens Herman²²,Haniffa Rashan²³²⁴,Hills Thomas²⁵,Horvat Christopher M.²⁶,Huang David T.¹⁹,Ichihara Nao²⁷,Lamontagne Francois²⁸,Marshall John C.¹³,McAuley Daniel F.²⁹³⁰,McGlothlin Anna³,McGuinness Shay P.²³¹,McVerry Bryan J.¹⁹,Neal Matthew D.¹⁹,Nichol Alistair D.²³²,Parke Rachael L.³¹³³,Parker Jane C.²,Parry-Billings Karen⁶,Peters Sam E. C.⁶,Reyes Luis F.³⁴³⁵,Rowan Kathryn M.⁶,Saito Hiroki³⁶,Santos Marlene S.¹³,Saunders Christina T.³,Serpa-Neto Ary²³⁷,Seymour Christopher W.¹⁹,Shankar-Hari Manu³⁸³⁹,Stronach Lucy M.⁷,Turgeon Alexis F.⁴⁰⁴¹,Turner Anne M.²⁵,van de Veerdonk Frank L.⁴²,Zarychanski Ryan⁴³,Green Cameron²,Lewis Roger J.³⁴⁴,Angus Derek C.¹⁹,McArthur Colin J.³¹,Berry Scott³,Derde Lennie P. G.¹²,Gordon Anthony C.⁷⁴⁵,Webb Steve A.²⁴⁶,Lawler Patrick R.²⁰²¹

Affiliation:

1. Writing Committee for the REMAP-CAP Investigators

2. Monash University, Melbourne, Victoria, Australia

3. Berry Consultants, Austin, Texas

4. University of British Columbia, Vancouver, British Columbia, Canada

5. Monash Health, Melbourne, Victoria, Australia

6. Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom

7. Imperial College London, London, United Kingdom

8. Hospital Raymond Poincaré (Assistance Publique Hôpitaux de Paris), Garches, France

9. Université Versailles SQY – Université Paris Saclay, Montigny-le-Bretonneux, France

10. King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia

11. University of Oxford, Oxford, United Kingdom

12. University Medical Center Utrecht, Utrecht, the Netherlands

13. St Michael’s Hospital Unity Health, Toronto, Ontario, Canada

14. University of Bristol, Bristol, United Kingdom

15. Jena University Hospital, Jena, Germany

16. Global Coalition for Adaptive Research

17. Yong Loo Lin Scholle of Medicine, National University Singapore, Singapore

18. NHS Blood and Transplant, Oxford, United Kingdom

19. University of Pittsburgh, Pittsburgh, Pennsylvania

20. Peter Munk Cardiac Centre at University Health Network, Toronto, Ontario, Canada

21. University of Toronto, Toronto, Ontario, Canada

22. University of Antwerp, Antwerp, Belgium

23. University of Oxford, Bangkok, Thailand

24. National Intensive Care Surveillance (NICST), Colombo, Sri Lanka

25. Medical Research Institute of New Zealand (MRINZ), Wellington, New Zealand

26. UPMC Children’s Hospital of Pittsburg, Pittsburg, Pennsylvania

27. University of Tokyo, Tokyo, Japan

28. Université de Sherbrooke, Sherbrooke, Québec, Canada

29. Queen’s University Belfast, Belfast, Northern Ireland

30. Royal Victoria Hospital, Belfast, Northern Ireland

31. Auckland City Hospital, Auckland, New Zealand

32. University College Dublin, Dublin, Ireland

33. University of Auckland, Auckland, New Zealand

34. Universidad de La Sabana, Chia, Colombia

35. Clinica Universidad de La Sabana, Chia, Colombia

36. St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan

37. Hospital Israelita Albert Einstein, Sao Paulo, Brazil

38. King’s College London, London, United Kingdom

39. Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

40. Université Laval, Québec City, Québec, Canada

41. CHU de Québec-Université Laval Research Center, Québec City, Canada

42. Radboud University Medical Center, Nijmegen, the Netherlands

43. University of Manitoba, Winnipeg, Manitoba, Canada

44. Harbor-UCLA Medical Center, Torrance, California

45. Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, United Kingdom

46. St John of God Hospital, Subiaco, Australia

Abstract

ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR &gt;0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2799870/jama_higgins_2022_oi_220139_1671563398.8122.pdf

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