Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

Author:

,Angus Derek C.12,Derde Lennie34,Al-Beidh Farah5,Annane Djillali678,Arabi Yaseen9,Beane Abigail10,van Bentum-Puijk Wilma3,Berry Lindsay11,Bhimani Zahra12,Bonten Marc313,Bradbury Charlotte1415,Brunkhorst Frank16,Buxton Meredith17,Buzgau Adrian18,Cheng Allen C.1920,de Jong Menno21,Detry Michelle11,Estcourt Lise2223,Fitzgerald Mark11,Goossens Herman24,Green Cameron20,Haniffa Rashan2526,Higgins Alisa M.20,Horvat Christopher12,Hullegie Sebastiaan J.3,Kruger Peter27,Lamontagne Francois28,Lawler Patrick R.29,Linstrum Kelsey1,Litton Edward30,Lorenzi Elizabeth11,Marshall John1231,McAuley Daniel32,McGlothin Anna11,McGuinness Shay20333435,McVerry Bryan36,Montgomery Stephanie12,Mouncey Paul37,Murthy Srinivas38,Nichol Alistair20394041,Parke Rachael33343542,Parker Jane20,Rowan Kathryn37,Sanil Ashish11,Santos Marlene12,Saunders Christina11,Seymour Christopher12,Turner Anne35,van de Veerdonk Frank43,Venkatesh Balasubramanian4445,Zarychanski Ryan46,Berry Scott11,Lewis Roger J.114748,McArthur Colin3549,Webb Steven A.203050,Gordon Anthony C.5

Affiliation:

1. The Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

2. The UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania

3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

4. Intensive Care Center, University Medical Center Utrecht, Utrecht, the Netherlands

5. Division of Anaesthetics, Pain Medicine and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom

6. Intensive Care Unit, Raymond Poincaré Hospital (AP-HP), Paris, France

7. Simone Veil School of Medicine, University of Versailles, Versailles, France

8. University Paris Saclay, Garches, France

9. Intensive Care Department, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia

10. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

11. Berry Consultants LLC, Austin, Texas

12. Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada

13. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands

14. Bristol Royal Informatory, Bristol, United Kingdom

15. University of Bristol, Bristol, United Kingdom

16. Center for Clinical Studies and Center for Sepsis Control and Care (CSCC), Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany

17. Global Coalition for Adaptive Research, San Francisco, California

18. Helix, Monash University, Melbourne, Victoria, Australia

19. Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Victoria, Australia

20. Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

21. Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, the Netherlands

22. NHS Blood and Transplant, Bristol, United Kingdom

23. Transfusion Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom

24. Department of Microbiology, Antwerp University Hospital, Antwerp, Belgium

25. Network for Improving Critical Care Systems and Training, Colombo, Sri Lanka

26. Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand

27. Intensive Care Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia

28. Université de Sherbrooke, Sherbrooke, Quebec, Canada

29. Cardiac Intensive Care Unit, Peter Munk Cardiac Centre, University Health Network, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada

30. School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia

31. Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada

32. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom

33. Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand

34. The Health Research Council of New Zealand, Wellington, New Zealand

35. Medical Research Institute of New Zealand, Wellington, New Zealand

36. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

37. Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom

38. University of British Columbia School of Medicine, Vancouver, Canada

39. Department of Anesthesia and Intensive Care, St Vincent’s University Hospital, Dublin, Ireland

40. School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland

41. Department of Intensive Care, Alfred Health, Melbourne, Victoria, Australia

42. School of Nursing, University of Auckland, Auckland, New Zealand

43. Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

44. Southside Clinical Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia

45. The George Institute for Global Health, Sydney, Australia

46. Department of Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada

47. Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California

48. Department of Emergency Medicine, David Geffen School of Medicine at University of California, Los Angeles

49. Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand

50. St John of God Hospital, Subiaco, Western Australia, Australia

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference23 articles.

1. Drug treatments for COVID-19: living systematic review and network meta-analysis.;Siemieniuk;BMJ,2020

2. Corticosteroids for treating sepsis in children and adults.;Annane;Cochrane Database Syst Rev,2019

3. Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV infection.;Ewald;Cochrane Database Syst Rev,2015

4. Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis.;Ye;CMAJ,2020

5. Corticosteroids as adjunctive therapy in the treatment of influenza: an updated Cochrane systematic review and meta-analysis.;Lansbury;Crit Care Med,2020

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