Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption

Author:

Zheng Shaokai1ORCID,Zhao Nannan1,Lin Xiaojun1,Qiu Lianglin1

Affiliation:

1. School of Public Health , Nantong University , Nantong , P.R. China

Abstract

Abstract Exposure to PM2.5 is the most significant air pollutant for health risk. The testosterone level in male is vulnerable to environmental toxicants. In the past, researchers focused more attention on the impacts of PM2.5 on respiratory system, cardiovascular system, and nervous system, and few researchers focused attention on the reproductive system. Recent studies have reported that PM2.5 involved in male testosterone biosynthesis disruption, which is closely associated with male reproductive health. However, the underlying mechanisms by which PM2.5 causes testosterone biosynthesis disruption are still not clear. To better understand its potential mechanisms, we based on the existing scientific publications to critically and comprehensively reviewed the role and potential mechanisms of PM2.5 that are participated in testosterone biosynthesis in male. In this review, we summarized the potential mechanisms of PM2.5 triggering the change of testosterone level in male, which involve in oxidative stress, inflammatory response, ferroptosis, pyroptosis, autophagy and mitophagy, microRNAs (miRNAs), endoplasmic reticulum (ER) stress, and N6-methyladenosine (m6A) modification. It will provide new suggestions and ideas for prevention and treatment of testosterone biosynthesis disruption caused by PM2.5 for future research.

Funder

Major Projects of Natural Sciences of University in Jiangsu Province of China

a project fund of Basic Scientific Research program of Nantong City

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

an innovation project of graduate student scientific research in Jiangsu province

Scientific Research Starting Foundation for The Doctoral researcher of Nantong University

Publisher

Walter de Gruyter GmbH

Subject

Public Health, Environmental and Occupational Health,Pollution,Health (social science)

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