Isolation and Characterization of Cytotoxic Diterpenoid Isomers from Propolis-Reference-Cited by-同舟云学术

Isolation and Characterization of Cytotoxic Diterpenoid Isomers from Propolis

Published:1997-10-01 Issue:9-10 Volume:52 Page:702-704
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Matsuno Tetsuya¹,Matsumoto Yasuyuki²,Saito Masahiro²,Morikawa Junji²

Affiliation:

1. National Institute of Health, Gakuen, Musashimurayama, Tokyo 208, Japan

2. Eiken Chemical Co., Ltd. 1-33-8 Hongo, Bunkyo-ku. Tokyo 113, Japan

Abstract

The methanol extract of Brazilian propolis was fractionated by HPLC, based on HuH13 (human hepatocellular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H30O3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-n-oic acid)

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-1997-9-1020/pdf

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