Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus Callus-Reference-Cited by-同舟云学术

Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus Callus

Published:2002-06-01 Issue:5-6 Volume:57 Page:465-470
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Marfori Eufrocinio C.¹,Kajiyama Shin’ichiro¹,Fukusaki Ei-ichiro¹,Kobayashi Akio¹

Affiliation:

1. Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita-shi, Osaka 565-0871, Japan

Abstract

The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite equisetin. This compound however, was not produced in the individual culture of T. harzianum or C. roseus callus.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2002-5-611/pdf

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