Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium

Author:

Huang Ziwei,Zhu Wangjie,Bai Yifan,Bai Xuelian,Zhang Huawei

Abstract

AbstractFungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with diverse structural motifs and various biological properties. With the continuous improvement and extensive application of bioinformatic tools (e.g., anti-SMASH, NCBI, UniProt), more and more biosynthetic gene clusters (BGCs) of secondary metabolites (SMs) have been identified in Fusarium strains. However, the biosynthetic logics of these SMs have not yet been well investigated till now. With the aim to increase our knowledge of the biosynthetic logics of NPRS-encoding products in Fusarium, this review firstly provides an overview of research advances in elucidating their biosynthetic pathways.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

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