Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
Author:
Bazyar Hadi1, Hosseini Seyed Ahmad2, Saradar Sirous3, Mombaini Delsa2, Allivand Mohammad2, Labibzadeh Maryam4, Alipour Meysam5ORCID
Affiliation:
1. Student Research Committee , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran 2. Nutrition and Metabolic Diseases Researcher Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran 3. Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran 4. Institute for Higher Education ACECR , Khouzestan , Iran 5. Alimentary Tract Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran
Abstract
Abstract
Background
In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown.
Objectives
Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM.
Methods
In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention.
Results
The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05).
Conclusions
This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.
Publisher
Walter de Gruyter GmbH
Subject
Complementary and alternative medicine
Reference32 articles.
1. Javid, AZ, Hosseini, SA, Gholinezhad, H, Moradi, L, Haghighi-zadeh, MH, Bazyar, H. Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity. Targets and Therapy 2020;13:753–61. 2. Ogurtsova, K, da Rocha Fernandes, J, Huang, Y, Linnenkamp, U, Guariguata, L, Cho, N, et al.. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017;128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024. 3. Bazyar, H, Adibmanesh, A, Javid, AZ, Maghsoumi-Norouzabad, L, Gravand, E, Alipour, M, et al.. The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obes Med 2019;16:100138. https://doi.org/10.1016/j.obmed.2019.10013. 4. Tiwari, BK, Pandey, KB, Abidi, A, Rizvi, SI. Markers of oxidative stress during diabetes mellitus. J Biomark 2013;2013:378790. https://doi.org/10.1155/2013/378790. 5. Rehman, K, Akash, MSH. Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked?. J Cell Biochem 2017;118:3577–85. https://doi.org/10.1002/jcb.26097.
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