Affiliation:
1. Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University Guangzhou China
2. Guangdong Provincial TCM Key Laboratory for Metabolic Diseases Guangzhou China
Abstract
AbstractGlucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, with mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, nuclear factor (erythroid‐derived 2)‐like 2, glucose transporter type 4, and phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, a comprehensive summary of the flavonoid effects on GLMD is lacking. This study reviewed the roles and mechanisms of natural flavonoids with different structures in the treatment of GLMD reported globally in the past 5 years and provides a reference for developing flavonoids as drugs for treating GLMD.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province
National Natural Science Foundation of China-Guangdong Joint Fund