Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells
Author:
Affiliation:
1. Department of Pharmaceutical Analysis, School of pharmacology, China Pharmaceutical University
2. Nanjing Syrois Pharmaceutical Co., Ltd.
3. Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/43/10/43_b20-00325/_pdf
Reference54 articles.
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3. 3) Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science, 247, 824–830 (1990).
4. 4) Hochhaus A, Kreil S, Corbin AS, La Rosée P, Muller MC, Lahaye T, Hanfstein B, Schoch C, Cross NC, Berger U, Gschaidmeier H, Druker BJ, Hehlmann R. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia, 16, 2190–2196 (2002).
5. 5) Volpe G, Panuzzo C, Ulisciani S, Cilloni D. Imatinib resistance in CML. Cancer Lett., 274, 1–9 (2009).
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