Investigation of the Intestinal Permeability and First-Pass Metabolism of Drugs in Cynomolgus Monkeys Using Single-Pass Intestinal Perfusion
Author:
Affiliation:
1. Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd.
2. Asia Development Department, Daiichi-Sankyo Co., Ltd.
3. Faculty of Pharmaceutical Sciences, Setsunan University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
http://www.jstage.jst.go.jp/article/bpb/33/1/33_1_111/_pdf
Reference37 articles.
1. Marked species differences in the bioavailability of midazolam in cynomolgus monkeys and humans
2. Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey
3. Characterization of Gastrointestinal Drug Absorption in Cynomolgus Monkeys
4. The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans
5. The Site-Specific Transport and Metabolism of Tacrolimus in Rat Small Intestine
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