Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey-Reference-Cited by-同舟云学术

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Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey

Published:2007-04-30 Issue:8 Volume:35 Page:1275-1284
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Nishimura Tomohiro,Amano Nobuyuki,Kubo Yoshiyuki,Ono Midori,Kato Yukio,Fujita Hisashi,Kimura Yoshiaki,Tsuji Akira

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference38 articles.

1. Intestinal Expression and Metabolic Activity of the CYP3A Subfamily in Female Rats

2. The drug efflux–metabolism alliance: biochemical aspects

3. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes

4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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2. Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System;Pharmaceutics;2023-12-05

3. Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism;Xenobiotica;2023-03-04

4. Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase;Drug Metabolism and Disposition;2022-05-30

5. Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development;Journal of Neurotrauma;2020-11-15

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