Pharmacological Evidence Showing Significant Roles for Potassium Channels and CYP Epoxygenase Metabolites in the Relaxant Effects of Docosahexaenoic Acid on the Rat Aorta Contracted with U46619

Author:

Sato Kyosuke1,Chino Daisuke1,Nishioka Nanako1,Kanai Keisuke1,Aoki Mika1,Obara Keisuke1,Miyauchi Seiji2,Tanaka Yoshio1

Affiliation:

1. Department of Pharmacology, Toho University School of Pharmaceutical Sciences

2. Department of Pharmacokinetics, Toho University School of Pharmaceutical Sciences

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference48 articles.

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2. 2) Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S, JPHC Study Group. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation, 113, 195–202 (2006).

3. 3) León H, Shibata MC, Sivakumaran S, Dorgan M, Chatterley T, Tsuyuki RT. Effect of fish oil on arrhythmias and mortality: systematic review. BMJ, 337 (dec23 2), a2931 (2008).

4. 4) Moreno JJ, Mitjavila MT. The degree of unsaturation of dietary fatty acids and the development of atherosclerosis. J. Nutr. Biochem., 14, 182–195 (2003).

5. 5) Nakamura Y, Ueno Y, Tamaki S, Kadowaki T, Okamura T, Kita Y, Miyamatsu N, Sekikawa A, Takamiya T, El-Saed A, Sutton-Tyrrell K, Ueshima H. Fish consumption and early atherosclerosis in middle-aged men. Metabolism, 56, 1060–1064 (2007).

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