Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?-Reference-Cited by-同舟云学术

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Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?

Published:2020-04-12 Issue:5 Volume:16 Page:387-401
ISSN:1742-5255
Container-title:Expert Opinion on Drug Metabolism & Toxicology
language:en
Short-container-title:Expert Opinion on Drug Metabolism & Toxicology

Author:

Alluri Ravindra V.¹,Li Rui²,Varma Manthena V. S.³

Affiliation:

1. Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK

2. Modeling and Simulations, Medicine Design, Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA

3. ADME Sciences, Medicine Design, Worldwide Research and Development, Pfizer Inc., Groton, CT, USA

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/17425255.2020.1749595

Reference167 articles.

1. Quantitative Proteomics and Mechanistic Modeling of Transporter‐Mediated Disposition in Nonalcoholic Fatty Liver Disease

2. A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

3. Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

4. Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation

5. Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP 2C8 and OATP 1B Drug Substrates

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