A Convenient Synthesis of Rivaroxaban from (S)-Epichlorohydrin
Author:
Affiliation:
1. Zentiva k.s., Praha, Czech Republic
Publisher
Informa UK Limited
Subject
Organic Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/00304948.2020.1741300
Reference24 articles.
1. Discovery of the Novel Antithrombotic Agent 5-Chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): An Oral, Direct Factor Xa Inhibitor
2. Rivaroxaban
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4. Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
5. Discovery of N-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor
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1. Epoxide Hydrolases: Multipotential Biocatalysts;International Journal of Molecular Sciences;2023-04-15
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3. Review on Synthetic Approaches toward Rivaroxaban (Xarelto), an Anticoagulant Drug;Organic Process Research & Development;2022-07-22
4. Epoxide Syntheses and Ring-Opening Reactions in Drug Development;Catalysts;2020-09-27
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