Affiliation:
1. School of Pharmaceutical Sciences Nanjing Tech University 30 South Puzhu Road Nanjing 210000 China
Abstract
AbstractAn efficient synthesis of rivaroxaban has been accomplished by a sequence spanning five steps from 4‐morpholinoaniline and (S)‐2‐(oxiran‐2‐ylmethyl)isoindoline‐1,3‐dione with an overall yield of 44 %. This synthesis is concise, environmentally benign and cost‐effective, providing a good basis for the development of a new process for rivaroxaban.
Funder
National Natural Science Foundation of China