Discovery of N-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor-Reference-Cited by-同舟云学术

Discovery of N-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor

Published:2011-11-11 Issue:23 Volume:54 Page:8051-8065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hirayama Fukushi¹,Koshio Hiroyuki¹,Ishihara Tsukasa¹,Hachiya Shunichiro¹,Sugasawa Keizo¹,Koga Yuji¹,Seki Norio¹,Shiraki Ryouta¹,Shigenaga Takeshi¹,Iwatsuki Yoshiyuki¹,Moritani Yumiko¹,Mori Kenichi¹,Kadokura Takeshi²,Kawasaki Tomihisa²,Matsumoto Yuzo³,Sakamoto Shuichi⁴,Tsukamoto Shin-ichi¹

Affiliation:

1. Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

2. Development, Astellas Pharma Inc., 17-1, Hasune 3-chome, Itabashi-ku, Tokyo 174-8612, Japan

3. Drug Discovery Research, Astellas Pharma Inc., 2-3-11, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan

4. Technology Supply Chain & Manufacturing, Astellas Pharma Europe B.V., Elisabethhof 19, 2350 AC Leiderdorp, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200868m

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