Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity-Reference-Cited by-同舟云学术

Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

Published:2020-01-01 Issue:1 Volume:35 Page:665-671
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Krasavin Mikhail¹,Sharonova Tatiana¹,Sharoyko Vladimir¹,Zhukovsky Daniil¹,Kalinin Stanislav¹,Žalubovskis Raivis²³,Tennikova Tatiana¹,Supuran Claudiu T.⁴^ORCID

Affiliation:

1. Saint Petersburg State University, Saint Petersburg, Russian Federation

2. Latvian Institute of Organic Synthesis, Riga, Latvia

3. Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia

4. Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy

Funder

Russian Foundation for Basic Research

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1734800

Reference15 articles.

1. How tumours escape mass destruction

2. The Warburg Effect and the Hallmarks of Cancer

3. Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors

4. Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic h CA II and membrane-bound h CA IX isoforms

5. Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

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