7-Glutathione-pyrrole and 7-cysteine-pyrrole are potential carcinogenic metabolites of pyrrolizidine alkaloids
Author:
Affiliation:
1. National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA
Publisher
Informa UK Limited
Subject
Cancer Research,Health, Toxicology and Mutagenesis
Link
https://www.tandfonline.com/doi/pdf/10.1080/10590501.2017.1298358
Reference46 articles.
1. Primary Liver Tumours in Rats following Feeding with Alkaloids of Senecio jacobaea
2. Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease
3. Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation
4. Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
5. International Programme on Chemical Safety. Pyrrolizidine alkaloids health and safety guide. Health and Safety Criteria Guide 26; International Programme on Chemical Safety. Geneva, Switzerland: WHO; 1989:19.
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