Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid <i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts-Reference-Cited by-同舟云学术

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Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts

Published:2021-08-23 Issue:4 Volume:39 Page:357-372
ISSN:2689-6583
Container-title:Journal of Environmental Science and Health, Part C
language:en
Short-container-title:Journal of Environmental Science and Health, Part C

Author:

He Xiaobo¹,Xia Qingsu¹,Shi Qiang¹,Fu Peter P.¹

Affiliation:

1. National Center for Toxicological Research, Jefferson, AR, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Cancer Research

Link

https://www.tandfonline.com/doi/pdf/10.1080/26896583.2021.1954460

Reference31 articles.

1. Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation

2. Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids;Current Research in Toxicology;2024

2. Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements;Chemical Research in Toxicology;2023-01-27

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